Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

Investigation of Maternal and Fetal Exposure to an IgG2 Monoclonal Antibody Following Biweekly Intravaginal Administration to Cynomolgus Monkeys Throughout Pregnancy

Reproductive Toxicology, 2014

Moffat GJ, Davies R, Kwon G, Retter MW, Chellman GJ, Kanapuram S, ...
  • HESI - Health and Environmental Sciences Institute

To assess the potential for male-mediated drug transfer to their female partner and/or developing conceptus, vaginal uptake of a monoclonal antibody(mAb) biotherapeutic was assessed in cynomolgus monkeys.

Read more

The Use of Mode of Action Information in Risk Assessment: Quantitative Key Events/Dose-Response Framework for Modeling the Dose-Response for Key Events

Critical Reviews in Toxicology, 2014

Simon TW, Simons SS, Preston RJ, Boobis AR, Cohen SM, Doerrer NG, ...
  • HESI - Health and Environmental Sciences Institute

The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in silico) to advance the next-generation of chemical risk assessments.

Read more

A 21st Century Roadmap for Human Health Risk Assessment

Critical Reviews in Toxicology, 2014

Pastoor TP, Bachman AN, Bell DR, Cohen SM, Dellarco M, ...
  • HESI - Health and Environmental Sciences Institute

The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 31
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 31
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )
					WHERE 1=1  AND ( 
  wp_postmeta.meta_key = '_ilsi_date'
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 180, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 2582
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:23:55
                    [post_date_gmt] => 2016-05-05 01:23:55
                    [post_content] => 
                    [post_title] => Assessment of Fetal Exposure Risk Following Seminal Excretion of a Therapeutic IgG4 (T-IgG4) Monoclonal Antibody Using a Rabbit Model
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => assessment-of-fetal-exposure-risk-following-seminal-excretion-of-a-therapeutic-igg4-t-igg4-monoclonal-antibody-using-a-rabbit-model
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:23:55
                    [post_modified_gmt] => 2016-05-05 01:23:55
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2582
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 2576
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:24:00
                    [post_date_gmt] => 2016-05-05 01:24:00
                    [post_content] => 
                    [post_title] => Opportunities to Meet Clinical Cardio-Oncology Needs With New Approaches to Non-Clinical Safety Assessment.
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => opportunities-to-meet-clinical-cardio-oncology-needs-with-new-approaches-to-non-clinical-safety-assessment
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:24:00
                    [post_modified_gmt] => 2016-05-05 01:24:00
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2576
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 2614
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:20:35
                    [post_date_gmt] => 2016-05-05 01:20:35
                    [post_content] => 
                    [post_title] => Investigation of Maternal and Fetal Exposure to an IgG2 Monoclonal Antibody Following Biweekly Intravaginal Administration to Cynomolgus Monkeys Throughout Pregnancy
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => investigation-of-maternal-and-fetal-exposure-to-an-igg2-monoclonal-antibody-following-biweekly-intravaginal-administration-to-cynomolgus-monkeys-throughout-pregnancy
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:20:35
                    [post_modified_gmt] => 2016-05-05 01:20:35
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2614
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 2583
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:23:48
                    [post_date_gmt] => 2016-05-05 01:23:48
                    [post_content] => 
                    [post_title] => Evaluating Uncertainty to Strengthen Epidemiologic Data for Use in Human Health Risk Assessments
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => evaluating-uncertainty-to-strengthen-epidemiologic-data-for-use-in-human-health-risk-assessments
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:23:48
                    [post_modified_gmt] => 2016-05-05 01:23:48
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2583
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 2625
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:17:42
                    [post_date_gmt] => 2016-05-05 01:17:42
                    [post_content] => 
                    [post_title] => The Use of Mode of Action Information in Risk Assessment: Quantitative Key Events/Dose-Response Framework for Modeling the Dose-Response for Key Events
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-use-of-mode-of-action-information-in-risk-assessment-quantitative-key-eventsdose-response-framework-for-modeling-the-dose-response-for-key-events
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:17:42
                    [post_modified_gmt] => 2016-05-05 01:17:42
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2625
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 2617
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:20:31
                    [post_date_gmt] => 2016-05-05 01:20:31
                    [post_content] => 
                    [post_title] => A 21st Century Roadmap for Human Health Risk Assessment
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-21st-century-roadmap-for-human-health-risk-assessment
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:20:31
                    [post_modified_gmt] => 2016-05-05 01:20:31
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2617
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 2582
            [post_author] => 6
            [post_date] => 2016-05-04 20:23:55
            [post_date_gmt] => 2016-05-05 01:23:55
            [post_content] => 
            [post_title] => Assessment of Fetal Exposure Risk Following Seminal Excretion of a Therapeutic IgG4 (T-IgG4) Monoclonal Antibody Using a Rabbit Model
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => assessment-of-fetal-exposure-risk-following-seminal-excretion-of-a-therapeutic-igg4-t-igg4-monoclonal-antibody-using-a-rabbit-model
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-05-04 20:23:55
            [post_modified_gmt] => 2016-05-05 01:23:55
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => http://ilsi.org/hesi/?post_type=publication&p=2582
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 479
    [max_num_pages] => 80
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => df352e0d4ceb0a5296effe23dffb836e
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.