Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Normal Ranges and Variability of Novel Urinary Renal Biomarkers in Sprague-Dawley Rats: Comparison of Constitutive Values Between Males and Females and Across Assay Platforms

Toxicologic Pathology, 2014

Gautier JC, Gury T, Guffroy M, Khan-Malek R, Hoffman D, Pettit S, ...
  • HESI - Health and Environmental Sciences Institute

Differences were examined between male and female Sprague-Dawley rats in basal levels of a wide range of urinary biomarkers, including 7 recently qualified biomarkers.

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Nonclinical Safety Assessment of Engineered T Cell Therapies

Regulatory Toxicology and Pharmacology, 2021

Lebrec H, Maier CC, Maki K, Ponce R, Shenton J, & Green S

Over the last decade, immunotherapy has established itself as an important novel approach in the treatment of cancer, resulting in a growing importance in oncology. Engineered T cell therapies, namely chimeric antigen receptor (CAR) T cells and T cell receptor (TCR) T cell therapies, are platform technologies that have enabled ...

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Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability

PLOS One, 2017

Marjory B. Brooks, James R. Turk, Abraham Guerrero, ...
  • HESI - Health and Environmental Sciences Institute

This article characterizes a time course model of inflammation and hemostatic activation in rats treated with bacterial endotoxin (lipopolysaccharide, LPS) through a combination of traditional histologic and clinicopathologic endpoints and analyses of novel circulating biomarkers, including microRNA (miRNA) and ...

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Next-generation testing strategy for assessment of genomic damage: a conceptual framework and considerations.

Environmental and Molecular Mutagenesis, 2016

Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, ...
  • HESI - Health and Environmental Sciences Institute

 

To enable the broader context for examining genetic damage, a next generation testing strategy needs to take into account a broader, more flexible approach to testing, and ultimately modeling, of genomic damage as it relates to human exposure. The outline of a flexible ...

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New and Emerging Technologies for Genetic Toxicity Testing

Environmental and Molecular Mutagenesis, 2011

Lynch AM, Sasaki JC, Elespuru R, Jacobson‐Kram D, Thybaud V, ...
  • HESI - Health and Environmental Sciences Institute

The International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Project Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing established an Emerging Technologies and New Strategies Workgroup to review the current State of the Art in ...

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Contact Us

Health and Environmental Sciences Institute (HESI)

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