Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Value of Juvenile Animal Studies

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2011

Leconte I, Bailey G, Davis‐Bruno K, Hew KW, Kim J, Silva Lima B, ...
  • HESI - Health and Environmental Sciences Institute

The Developmental and Reproductive Toxicology Technical Committee of the ILSI Health and Environmental Sciences Institute has undertaken a project to address the impact of juvenile animal studies on pediatric drug development.

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Utilization of Juvenile Animal Studies to Determine the Human Effects and Risks of Environmental Toxicants During Postnatal Developmental Stages

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2004

Brent RL
  • HESI - Health and Environmental Sciences Institute

Toxicology studies utilizing animals and in vitro cellular or tissue preparations have been used to study the toxic effects and mechanism of action of drugs and chemicals and to determine the effective and safe dose of drugs in humans and the risk of toxicity from chemical exposures.

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Utility of a next-generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

Environmental and Molecular Mutagenesis, 2021

Nicolette J, Luijten M, Sasaki JC, Custer L, Embry M, Froetschl R, ...

The HESI Genetic Toxicology Technical Committee (GTTC) applies their systematic and flexible approach for assessing the risk of genetic damage due to exposure to chemical substances to etoposide, a drug used in certain types of cancer treatments, as a representative pharmaceutical case study.

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Using Mode of Action Information to Improve Regulatory Decision-Making: An ECETOC/HESI Workshop Overview

Critical Reviews in Toxicology, 2011

Carmichael N, Bausen M, Boobis AR, Cohen SM, Embry M, ...
  • HESI - Health and Environmental Sciences Institute

The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) and the Health and Environmental Sciences Institute (HESI) hosted a workshop in November 2009 to review current practice in the application of mode of action (MOA) considerations in chemical risk assessment.

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Using Exposure Bands for Rapid Decision Making in the RISK21 Tiered Exposure Assessment

Critical Reviews in Toxicology, 2017

Dellarco M, Zaleski R, Gaborek BJ, Qian H, Bellin CA, Egeghy P, ...

The Health and Environmental Sciences Institute (HESI) Risk Assessment in the 21st Century (RISK21) Committee was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent ...

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Health and Environmental Sciences Institute (HESI)

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