Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Qualitative Approach to Comparative Exposure in Alternatives Assessment

Integrated Environmental Assessment and Management, 2018

Greggs W, Burns T, Egeghy P, Embry MR, Fantke P, Gaborek B, ...
  • HESI - Health and Environmental Sciences Institute

Most alternatives assessments (AAs) published to date are largely hazard‐based rankings, thereby ignoring potential differences in human and/or ecosystem exposures; as such, they may not represent a fully informed consideration of the advantages and disadvantages of possible alternatives. Building on the 2014 US ...

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Protein and Lipid Binding Parameters in Rainbow Trout (Oncorhynchus Mykiss) Blood And Liver Fractions to Extrapolate From an In Vitro Metabolic Degradation Assay to In Vivo Bioaccumulation Potential of Hydrophobic Organic Chemicals

Chemical Research in Toxicology, 2011

Escher BI, Cowan-Ellsberry CE, Dyer S, Embry MR, Erhardt S, ...
  • HESI - Health and Environmental Sciences Institute

Binding of hydrophobic chemicals to colloids such as proteins or lipids is difficult to measure using classical microdialysis methods due to low aqueous concentrations, adsorption to dialysis membranes and test vessels, and slow kinetics of equilibration.

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Protease Resistance of Food Proteins: A Mixed Picture For Predicting Allergenicity but a Useful Tool for Assessing Exposure

Clinical and Translational Allergy, 2018

Akkerdaas J, Totis M, Barnett B, Bell E, Davis T, Edrington T, ...

Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological ...

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Proceedings of a Workshop on DNA Adducts: Biological Significance and Applications to Risk Assessment, Washington, DC, April 13–14, 2004

Toxicology and Applied Pharmacology, 2005

Sander M, Cadet J, Casciano DA, Galloway SM, Marnett LJ, Novak RF, ...
  • HESI - Health and Environmental Sciences Institute

In April 2004, the Health and Environmental Sciences Institute, a branch of the International Life Sciences Institute, with support from the National Institute of Environmental Health Sciences, organized a workshop to discuss the biological significance of DNA adducts.

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Problem Formulation for Risk Assessment of Combined Exposures to Chemicals and Other Stressors in Humans

Critical Reviews in Toxicology, 2016

Solomon KR, Wilks MF, Bachman A, Boobis A, Moretto A, Pastoor TP, ...

When the human health risk assessment/risk management paradigm was developed, it did not explicitly include a “problem formulation” phase. The concept of problem formulation was first introduced in the context of ecological risk assessment (ERA) for the pragmatic reason to constrain and focus ERAs on the key questions. ...

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