Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Goldman JM, Murr AS, Cooper RL
- HESI - Health and Environmental Sciences Institute
While an evaluation of the estrous cycle in laboratory rodents can be a useful measure of the integrity of the hypothalamic-pituitary-ovarian reproductive axis, it can also serve as a way of insuring that animals exhibiting abnormal cycling patterns are disincluded from a study prior to exposure to a test compound.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Hoyer PB, Sipes IG
- HESI - Health and Environmental Sciences Institute
The occupational chemical 4-vinylcyclohexene (VCH) has been shown to cause destruction of small pre-antral follicles in ovaries of mice.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Li S, Davis B
- HESI - Health and Environmental Sciences Institute
Interpreting histopathology of the female rodent reproductive tract can be challenging in toxicity studies.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Solleveld HA, Portelli ST, Wier PJ
- HESI - Health and Environmental Sciences Institute
Idoxifene is a selective estrogen receptor modulator similar to tamoxifen but is no longer in pharmaceutical development due to adverse genitourinary effects in the clinic.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Stanislaus DJ, Wier PJ
- HESI - Health and Environmental Sciences Institute
Observations associated with drug-induced hyper- or hypoprolactinemia in rat toxicology studies may be similar and include increased ovarian weight due to increased presence of corpora lutea.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Stanislaus DJ, Williams AM
- HESI - Health and Environmental Sciences Institute
This report describes normal histology of tissues from immature female dogs and sequential microscopic changes that occur during different stages of the estrous cycle in ovary, uterus, vagina and mammary glands.
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