Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Simulation of Mouse and Rat Spermatogenesis to Inform Genotoxicity Testing Using OECD Test Guideline 488

Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2018

Marchetti F, Aardema MJ, Beevers C, van Benthem J, Douglas GR, ...

The Germ Cell Workgroup of the Genetic Toxicology (GTTC) Committee of the Health and Environmental Sciences Institute modeled mouse and rat spermatogenesis to better define the exposure history of the cell population collected from seminiferous tubules.

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.

J Pharmacol Toxicol Methods., 2018

Chiang AY, Guth BD, Pugsley MK, Foley CM, Doyle JM, Engwall MJ, ...
  • HESI - Health and Environmental Sciences Institute

The HESI Cardiac Safety Committee designed and conducted studies to evaluate inherent variability in telemetry implanted dogs. This paper discusses details of the statistical methods used to evaluate a primary endpoint for measuring blood pressure changes.

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Rethinking Developmental Toxicity Testing: Evolution or Revolution?

Birth Defects Research, 2018

Scialli AR, Daston G, Chen C, Coder PS, Euling SY, Foreman J, ...

Summary from the HESI workshop on embryo‐fetal development testing, considers how we might design developmental toxicity testing if we started over with 21st century knowledge and techniques. The paper considers what might make current protocols more predictive for human risk.

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Health and Environmental Sciences Institute (HESI)

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