Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Comparison of Immune System Development in Nonclinical Species and Humans: Closing Information Gaps for Immunotoxicity Testing and Human Translatability

Reproductive Toxicology, 2019

Skaggs H, Chellman GJ, Collinge M, Enright B, Fuller CL, Krayer J, ...
  • HESI - Health and Environmental Sciences Institute

The developmental origins of human health and disease (DOHaD) is a growing field of health-related research that is based on the hypothesis that perturbations to the pre- or postnatal environment, in the form of xenobiotic exposure, stress, infections or nutritional deficits, may contribute to the manifestation of disease ...

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Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

Critical Reviews in Toxicology , 2016

Peter T. Theunissen, Sonja Beken, Bruce K. Beyer, ...
  • HESI - Health and Environmental Sciences Institute

Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo–fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT testing could be limited to one species, or whether the testing in a second ...

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Comparisons of PNEC Derivation Logic Flows Under Example Regulatory Schemes and Implications for ecoTTC

Regulatory Toxicology and Pharmacology, 2021

Belanger SE, Beasley A, Brill JL, Krailler J, Connors KA, Carr GJ, ...

Derivation of Predicted No Effect Concentrations (PNECs) for aquatic systems is the primary deterministic form of hazard extrapolation used in environmental risk assessment. Depending on the data availability, different regulatory jurisdictions apply application factors (AFs) to the most sensitive measured endpoint to ...

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