Comparison of Immune System Development in Nonclinical Species and Humans: Closing Information Gaps for Immunotoxicity Testing and Human Translatability

  • Publication Date :
  • Publication Type : Journal Article
  • Author(s) : Skaggs H, Chellman GJ, Collinge M, Enright B, Fuller CL, Krayer J, Sivaraman L, Weinbauer GF
  • Journal Name : Reproductive Toxicology

The developmental origins of human health and disease (DOHaD) is a growing field of health-related research that is based on the hypothesis that perturbations to the pre- or postnatal environment, in the form of xenobiotic exposure, stress, infections or nutritional deficits, may contribute to the manifestation of disease later in life. Within the field of DOHaD, developmental immunotoxicology (DIT) is emerging as an important discipline due to the potential for DIT to result in adverse health outcomes related to immune system dysfunction

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