Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Protease Resistance of Food Proteins: A Mixed Picture For Predicting Allergenicity but a Useful Tool for Assessing Exposure

Clinical and Translational Allergy, 2018

Akkerdaas J, Totis M, Barnett B, Bell E, Davis T, Edrington T, ...

Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological ...

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Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Toxicological Sciences, 2018

Nichols J, Fay K, Bernhard MJ, Bischof I, Davis J, Halder M, Hu J, ...

The HESI Bioaccumulation Technical Committee completed a study highlighting several issues related to the demonstration of assay reliability and provided a template for evaluating other in vitro biotransformation assays. The results are published here.

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Identifying Germ Cell Mutagens Using OECD Test Guideline 488 (Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays) and Integration with Somatic Cell Testing

Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2018

Marchetti F, Aardema MJ, Beevers C, van Benthem J, Godschalk R, ...

The Organisation for Economic Co-operation and Development Test Guideline 488 (TG 488) provides recommendations for assessing germ cell and somatic cell mutagenicity using transgenic rodent (TGR) models. However, important data gaps exist for selecting an optimal approach for simultaneously evaluating mutagenicity in ...

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Variation in Seed Allergen Content From Three Varieties of Soybean Cultivated in Nine Different Locations in Iowa, Illinois, and Indiana

Frontiers in Plant Science, 2018

McClain S, Stevenson SE, Brownie C, Herouet-Guicheney C, ...

Soybean (Glycine max) is an important food stock, and also considered an allergenic food with at least eight well characterized allergens. However, it is a less prevalent allergen source than many other foods and is rarely life-threatening. Soybean is incorporated into commonly consumed foods, and therefore, the allergens pose ...

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Qualitative Approach to Comparative Exposure in Alternatives Assessment

Integrated Environmental Assessment and Management, 2018

Greggs W, Burns T, Egeghy P, Embry MR, Fantke P, Gaborek B, ...
  • HESI - Health and Environmental Sciences Institute

Most alternatives assessments (AAs) published to date are largely hazard‐based rankings, thereby ignoring potential differences in human and/or ecosystem exposures; as such, they may not represent a fully informed consideration of the advantages and disadvantages of possible alternatives. Building on the 2014 US ...

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Do Current Approaches to Assessing Therapy Related Adverse Events Align with the Needs of Long-Term Cancer Patients and Survivors?

Cardio-Oncology, 2018

Syril D. Pettit, Rebecca Kirch
  • HESI - Health and Environmental Sciences Institute

The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not infrequent, outcome of these life-saving therapies. ...

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