Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Breslin WJ, Paulman A, Sun‐Lin D, Goldstein KM, Derr A
- HESI - Health and Environmental Sciences Institute
The objective of this study was to evaluate the utility of plasma Inhibin B (InhB) as a biomarker of testicular injury in adult rats following short-term exposure to the known Sertoli cell toxicants mono-2-ethylhexyl phthalate (MEHP), 1,3 dinitrobenzene (DNB), or carbendazim (CBZ).
Journal of Pharmacological and Toxicological Methods, 2023
Emmanuel Boulay, Loïs S. Miraucourt, Michael K. Pugsley, ...
Members of the HESI Cardiac Safety Committee pooled retrospective data to explore the incidence of spontaneous arrhythmias and effect of telemetry implants in species typically used in safety pharmacology studies.
Toxicological Sciences, 2020
Sutherland VL, McQueen CA, Mendrick D, Gulezian D, Cerniglia C, ...
- HESI - Health and Environmental Sciences Institute
There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, HESI held a workshop, “The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity” to identify data gaps in determining how gut ...
Aquatic Toxicology, 2010
Embry MR, Belanger SE, Braunbeck TA, Galay-Burgos M, Halder M, ...
- HESI - Health and Environmental Sciences Institute
Animal alternatives research has historically focused on human safety assessments and has only recently been extended to environmental testing.
J Pharmacol Toxicol Methods., 2018
Chiang AY, Guth BD, Pugsley MK, Foley CM, Doyle JM, Engwall MJ, ...
- HESI - Health and Environmental Sciences Institute
The HESI Cardiac Safety Committee designed and conducted studies to evaluate inherent variability in telemetry implanted dogs. This paper discusses details of the statistical methods used to evaluate a primary endpoint for measuring blood pressure changes.
Journal of Pharmacological and Toxicological Methods, 2015
Guth BD, Chiang AY, Doyle J, Engwall MJ, Guillon JM, Hoffmann P, ...
- HESI - Health and Environmental Sciences Institute
Drug-induced effects on the cardiovascular system remain a major cause of drug attrition.
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