Methapyrilene (MP) exposure of animals can result in an array of adverse pathological responses including hepatotoxicity.
Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations
Toxicologic Pathology, 2002
The mission of HESI’s Emerging Systems Toxicology for the Assessment of Risk (eSTAR) Committee is to develop and deliver innovative systems toxicology approaches for risk assessment. The committee aims to catalyze adoption of new translational and predictive tools that guide decision-making based on mechanistic understanding of toxicological response.
A manuscript was accepted describing the group’s strategy to create transcriptomic biomarkers for particular pathways leading to rat tumors. Current work is to derive and refine the biomarkers. There is also planned experimental work to see gene expression difference in wild type and knock out rats in response to reference compounds.
This newly formed group is planning a proof of concept study to see if Cell Painting data (with or without transcriptomic data) can be predictive of existing rat liver data.
This newly formed group is exploring the use of error corrected sequencing to detect clonal expansion of non-genotoxic carcinogens.
A manuscript on DNA de-modification analysis of clinical tumor samples was accepted; the project will sunset after an educational webinar.
Designed and launched a multi-site experimental program on the use of exosomal miRNAs expressed in response to renal toxicants.
The HESI eSTAR committee is proud to announce that it was awarded a $250,000 USD grant (U01) as part of the USFDA’s Biomarker Qualification Program in June 2022. This funding will be partnered with Committee resources to support a four-site ring trial generating additional data on the TGx-DDI (TGx = toxicogenomics; DDI = DNA damage inducing) biomarker. The TgX-DDI biomarker is currently under review by the FDA as part of the FDA Biomarker Qualification program. Pending the results of this final study, the marker is anticipated to gain FDA approval for optional use as added weight of evidence in the assessment of genotoxicity. The marker has the potential to improve upon the low specificity of in vitro chromosome damage assays used in current testing and to aid drug development by providing mechanistic insights into transcriptional changes occurring in genes involved in key DNA damage pathways.
Learn more about the use of the TGx-DDI transcriptomic biomarker for the genotoxicity assessment of data-poor chemicals here (poster presented at the 2021 EMGS Virtual Annual Meeting by Anne-Marie Fortin, University of Ottawa).
This Working Group has compiled a broad membership of experts across sectors and chemical classes to write a recently accepted manuscript on the state of the science on the use and potential applications of transcriptomic PODs. Future work will include discussion of bioinformatic methods to derive transcriptomic PODs.
Toxicologic Pathology, 2002
Methapyrilene (MP) exposure of animals can result in an array of adverse pathological responses including hepatotoxicity.
2003
This book chapter was published in Toxicogenomics.
Environmental Health Perspectives, 2004
This study, designed and conducted as part of the International Life Sciences Institute working group on the Application of Genomics and Proteomics, examined the changes in the expression profile of genes associated with the administration of three different nephrotoxicants--cisplatin, gentamicin, and puromycin--to ...
Environmental Health Perspectives, 2004
Microarrays have the potential to significantly impact our ability to identify toxic hazards by the identification of mechanistically relevant markers of toxicity.
Environmental Health Perspectives, 2004
Consistency and coherence of gene expression data across multiple sites depends on several factors such as platform (oligo, cDNA, etc.), environmental conditions at each laboratory, and data quality.
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2004
Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell death.
Director, Center for Patient and Consumer Safety (CPCS)
spettit@hesiglobal.orgGlaxoSmithKline
National Institute of Environmental Health Sciences
Syngenta
May 13, 2024
Webinar, Global
On May 13, 2024, several esteemed members from HESI’s Genetic Toxicology Technical Committee (GTTC) and Emerging Systems Toxicology for the Assessment of Risk Committee (eSTAR) delivered insightful presentations at the FDA's CDER Pharmacology Toxicology Symposium. This event, organized by the Education Subcommittee, ...
September 7, 2024 – September 11, 2024
Palm Springs, CA, USA
Science from the HESI Genetic Toxicology (GTTC) and Emerging Systems Toxicology for the Assessment of Risk (eSTAR) committees will be well represented at the 55th Annual Meeting of the Environmental Mutagenesis and Genomics Society (EMGS) in Palm Springs, California.
September 8, 2024 – September 11, 2024
Copenhagen, Denmark
Members of the HESI DART, eSTAR and GTTC Committees will be in attendance at EUROTOX 2024 taking place September 8-11 in Copenhagen.
November 13, 2024 – November 14, 2024
HESI eSTAR Committee, Virtual
The HESI Emerging Systems Toxicology for Assessment of Risk (eSTAR) Committee invites you to attend their free, virtual, 2024 Annual Meeting.
November 21, 2024
HESI OASIS Consortium Members Presenting, eSTAR Committee
Join HESI OASIS Consortium members David Rouquie (Bayer) and Jessica Ewald (Broad Institute) for an exciting installment of the DyNAMic Discussions webinar series, where experts share their experiences in overcoming barriers to applying New Approach Methodologies (NAMs) in their fields. This seminar series offers candid ...
February 13, 2025 – February 14, 2025
Virtual, Online
hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-8403
740 15th Street NW, Suite 600
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