eSTAR

Emerging Systems Toxicology for the Assessment of Risk (eSTAR) Committee

Mission Statement

The mission of HESI’s Emerging Systems Toxicology for the Assessment of Risk (eSTAR) Committee is to develop and deliver innovative systems toxicology approaches for risk assessment. The committee aims to catalyze adoption of new translational and predictive tools that guide decision-making based on mechanistic understanding of toxicological response.

Working Groups

  • Carcinogenomics Project

    A manuscript was accepted describing the group’s strategy to create transcriptomic biomarkers for particular pathways leading to rat tumors. Current work is to derive and refine the biomarkers. There is also planned experimental work to see gene expression difference in wild type and knock out rats in response to reference compounds.

  • Cell Painting - Oasis Consortium

    This newly formed group is planning a proof of concept study to see if Cell Painting data (with or without transcriptomic data) can be predictive of existing rat liver data.

  • Error Corrected Sequencing

    This newly formed group is exploring the use of error corrected sequencing to detect clonal expansion of non-genotoxic carcinogens.

  • FFPE Project

    A manuscript on DNA de-modification analysis of clinical tumor samples was accepted; the project will sunset after an educational webinar.

  • miRNA Biomarkers Project

    Designed and launched a multi-site experimental program on the use of exosomal miRNAs expressed in response to renal toxicants.

  • TGx-DDI Project

    The HESI eSTAR committee is proud to announce that it was awarded a $250,000 USD grant (U01) as part of the USFDA’s Biomarker Qualification Program in June 2022. This funding will be partnered with Committee resources to support a four-site ring trial generating additional data on the TGx-DDI (TGx = toxicogenomics; DDI = DNA damage inducing) biomarker. The TgX-DDI biomarker is currently under review by the FDA as part of the FDA Biomarker Qualification program. Pending the results of this final study, the marker is anticipated to gain FDA approval for optional use as added weight of evidence in the assessment of genotoxicity. The marker has the potential to improve upon the low specificity of in vitro chromosome damage assays used in current testing and to aid drug development by providing mechanistic insights into transcriptional changes occurring in genes involved in key DNA damage pathways.

    Learn more about the use of the TGx-DDI transcriptomic biomarker for the genotoxicity assessment of data-poor chemicals here (poster presented at the 2021 EMGS Virtual Annual Meeting by Anne-Marie Fortin, University of Ottawa).

  • Use of Transcriptomic Point of Departure (POD) for Chemical Risk Assessments

    This Working Group has compiled a broad membership of experts across sectors and chemical classes to write a recently accepted manuscript on the state of the science on the use and potential applications of transcriptomic PODs. Future work will include discussion of bioinformatic methods to derive transcriptomic PODs.

Recent Highlights

 

HESI OASIS Consortium receives $1.2 million USD grant

The OASIS Consortium, a working group within HESI’s Emerging Systems Toxicology for the Assessment of Risk (eSTAR) Committee, received $1.2 million from the Massachusetts Life Sciences Center Bytes to Bytes Awards. These funds, supplemented with $2.5 from industry, will support laboratory work at the Broad Institute of Harvard and MIT to investigate Cell Painting, transcriptomics, and proteomics for decision making in toxicology. These funds also support two postdocs positions at the Broad Institute. This 3-year project will explore approximately 1600 compounds across 3 cell types, organoids, and microphysiological systems.

Read the full press release here.

 

TGx-DDI Project receives FDA Funding

The HESI eSTAR committee is proud to announce that it was awarded a $250,000 USD grant (U01) as part of the USFDA’s Biomarker Qualification Program in June 2022. This funding will be partnered with Committee resources to support a four-site ring trial generating additional data on the TGx-DDI (TGx = toxicogenomics; DDI = DNA damage inducing) biomarker. The TgX-DDI biomarker is currently under review by the FDA as part of the FDA Biomarker Qualification program. Pending the results of this final study, the marker is anticipated to gain FDA approval for optional use as added weight of evidence in the assessment of genotoxicity. The marker has the potential to improve upon the low specificity of in vitro chromosome damage assays used in current testing and to aid drug development by providing mechanistic insights into transcriptional changes occurring in genes involved in key DNA damage pathways.

Committee Publications

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Identification of Putative Gene Based Markers of Renal Toxicity

Environmental Health Perspectives, 2004

Amin RP, Vickers AE, Sistare F, Thompson KL, Roman RJ, Lawton M, ...
  • HESI - Health and Environmental Sciences Institute

This study, designed and conducted as part of the International Life Sciences Institute working group on the Application of Genomics and Proteomics, examined the changes in the expression profile of genes associated with the administration of three different nephrotoxicants--cisplatin, gentamicin, and puromycin--to ...

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Cross-Site Comparison Of Gene Expression Data Reveals High Similarity

Environmental Health Perspectives, 2004

Chu TM, Deng S, Wolfinger R, Paules RS, Hamadeh HK
  • HESI - Health and Environmental Sciences Institute

Consistency and coherence of gene expression data across multiple sites depends on several factors such as platform (oligo, cDNA, etc.), environmental conditions at each laboratory, and data quality.

Read more

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Committee Resources

HESI Staff

Leadership Team

  • Deidre Dalmas Wilk, PhD

    GlaxoSmithKline

  • Scott Auerbach, PhD

    National Institute of Environmental Health Sciences

  • John Rooney, PhD

    Syngenta

Committee Events

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EUROTOX 2024

September 8, 2024 – September 11, 2024

Copenhagen, Denmark

Members of the HESI DART, eSTAR and GTTC Committees will be in attendance at EUROTOX 2024 taking place September 8-11 in Copenhagen.

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FDA’s CDER Pharmacology Toxicology Symposium

May 13, 2024

Webinar, Global

On May 13, 2024, several esteemed members from HESI’s Genetic Toxicology Technical Committee (GTTC) and Emerging Systems Toxicology for the Assessment of Risk Committee (eSTAR) delivered insightful presentations at the FDA's CDER Pharmacology Toxicology Symposium. This event, organized by the Education Subcommittee, ...

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                    [1] => Array
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                                    [key] => _ilsi_date
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                                    [compare] => <=
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                            [1] => Array
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                                    [key] => _ilsi_end_date
                                    [value] => 2050-01-01
                                    [compare] => <=
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                            [relation] => AND
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                    [relation] => AND
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                    [1] => mt1
                    [2] => mt2
                )

            [clauses:protected] => Array
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                    [wp_postmeta] => Array
                        (
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                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
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                    [mt1] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                            [compare_key] => =
                            [alias] => mt1
                            [cast] => CHAR
                        )

                    [mt2] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                            [compare_key] => =
                            [alias] => mt2
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
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    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )  INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )  INNER JOIN wp_postmeta AS mt2 ON ( wp_posts.ID = mt2.post_id )
					WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (143)
) AND ( 
  wp_postmeta.meta_key = '_ilsi_date' 
  AND 
  ( 
    ( mt1.meta_key = '_ilsi_date' AND mt1.meta_value <= '2050-01-01' ) 
    AND 
    ( mt2.meta_key = '_ilsi_end_date' AND mt2.meta_value <= '2050-01-01' )
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) AND ((wp_posts.post_type = 'event' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 0, 6
				
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                    [post_date] => 2024-09-25 12:53:31
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                    [post_content] => 
                    [post_title] => 2025 Society of Toxicology Annual Meeting and Tox Expo
                    [post_excerpt] => 
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                    [guid] => https://hesiglobal.org/?post_type=event&p=28582
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
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                    [post_author] => 16
                    [post_date] => 2024-09-20 19:24:16
                    [post_date_gmt] => 2024-09-20 19:24:16
                    [post_content] => 
                    [post_title] => 3rd International Conference Genotoxic Compounds
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => 3rd-international-conference-genotoxic-compounds
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                    [pinged] => 
                    [post_modified] => 2024-09-20 19:24:16
                    [post_modified_gmt] => 2024-09-20 19:24:16
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=28563
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                    [post_type] => event
                    [post_mime_type] => 
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            [2] => WP_Post Object
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                    [post_author] => 16
                    [post_date] => 2024-07-12 17:59:25
                    [post_date_gmt] => 2024-07-12 17:59:25
                    [post_content] => 
                    [post_title] => HESI Emerging Systems Toxicology for Assessment of Risk (eSTAR) Committee 2024 Annual Meeting
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => estar-2024-annual-meeting
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2024-10-03 14:17:27
                    [post_modified_gmt] => 2024-10-03 14:17:27
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/event/hesi-emerging-systems-toxicology-for-assessment-of-risk-estar-committee-2023-annual-meeting-copy/
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                    [post_type] => event
                    [post_mime_type] => 
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            [3] => WP_Post Object
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                    [post_author] => 16
                    [post_date] => 2024-07-08 19:27:50
                    [post_date_gmt] => 2024-07-08 19:27:50
                    [post_content] => 
                    [post_title] => EUROTOX 2024
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => eurotox-2024
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                    [post_modified] => 2024-09-05 13:23:32
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                    [guid] => https://hesiglobal.org/?post_type=event&p=28289
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            [4] => WP_Post Object
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                    [post_author] => 16
                    [post_date] => 2024-06-11 17:36:13
                    [post_date_gmt] => 2024-06-11 17:36:13
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                    [post_title] => 55th Annual Meeting of the Environmental Mutagenesis and Genomics Society (EMGS)
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                    [post_author] => 16
                    [post_date] => 2024-05-21 14:40:29
                    [post_date_gmt] => 2024-05-21 14:40:29
                    [post_content] => 
                    [post_title] => FDA's CDER Pharmacology Toxicology Symposium
                    [post_excerpt] => 
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                    [post_password] => 
                    [post_name] => fdas-cder-pharmacology-toxicology-symposium
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                    [guid] => https://hesiglobal.org/?post_type=event&p=28137
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                    [post_type] => event
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            [post_title] => 2025 Society of Toxicology Annual Meeting and Tox Expo
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