Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Solleveld HA, Portelli ST, Wier PJ
- HESI - Health and Environmental Sciences Institute
Idoxifene is a selective estrogen receptor modulator similar to tamoxifen but is no longer in pharmaceutical development due to adverse genitourinary effects in the clinic.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Stanislaus DJ, Wier PJ
- HESI - Health and Environmental Sciences Institute
Observations associated with drug-induced hyper- or hypoprolactinemia in rat toxicology studies may be similar and include increased ovarian weight due to increased presence of corpora lutea.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Stanislaus DJ, Williams AM
- HESI - Health and Environmental Sciences Institute
This report describes normal histology of tissues from immature female dogs and sequential microscopic changes that occur during different stages of the estrous cycle in ovary, uterus, vagina and mammary glands.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2008
Chapin R, Augustine‐Rauch K, Beyer B, Daston G, Finnell R, ...
- HESI - Health and Environmental Sciences Institute
A meeting was convened so that users of three models for in vitro developmental toxicity (embryonic stem cells, whole embryo culture, and zebrafish) could share their experiences with each model, and explore the areas for improvement.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2009
Marty MS, Allen B, Chapin RE, Cooper R, Daston GP, Flaws JA, ...
- HESI - Health and Environmental Sciences Institute
The U.S. EPA revised the Reproduction and Fertility Effects Test Guideline (OPPTS 870.3800/OECD 416) in 1998, adding numerous endpoints in an effort to incorporate new methodologies, improve the sensitivity for detecting reproductive toxicants, and more efficiently utilize study animals.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2010
Daston GP, Chapin RE, Scialli AR, Piersma AH, Carney EW, ...
- HESI - Health and Environmental Sciences Institute
There continue to be many efforts around the world to develop assays that are shorter than the traditional embryofetal developmental toxicity assay, or use fewer or no mammals, or use less compound, or have all three attributes.
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