Toxicology studies utilizing animals and in vitro cellular or tissue preparations have been used to study the toxic effects and mechanism of action of drugs and chemicals and to determine the effective and safe dose of drugs in humans and the risk of toxicity from chemical exposures.
Utilization of Juvenile Animal Studies to Determine the Human Effects and Risks of Environmental Toxicants During Postnatal Developmental Stages
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2004