To assess the potential for male-mediated drug transfer to their female partner and/or developing conceptus, vaginal uptake of a monoclonal antibody(mAb) biotherapeutic was assessed in cynomolgus monkeys.
Investigation of Maternal and Fetal Exposure to an IgG2 Monoclonal Antibody Following Biweekly Intravaginal Administration to Cynomolgus Monkeys Throughout Pregnancy
Reproductive Toxicology, 2014