Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2009
Marty MS, Allen B, Chapin RE, Cooper R, Daston GP, Flaws JA, ...
- HESI - Health and Environmental Sciences Institute
The U.S. EPA revised the Reproduction and Fertility Effects Test Guideline (OPPTS 870.3800/OECD 416) in 1998, adding numerous endpoints in an effort to incorporate new methodologies, improve the sensitivity for detecting reproductive toxicants, and more efficiently utilize study animals.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Erdos Z, Pearson K, Goedken M, Menzel K, Sistare FD, Glaab WE, ...
- HESI - Health and Environmental Sciences Institute
Inhibin B is a heterodimer glycoprotein that downregulates follicle-stimulating hormone and is produced predominantly by Sertoli cells.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Stewart J, Bickerton S, Betts CJ, Kirk S
- HESI - Health and Environmental Sciences Institute
Inhibin B was measured in plasma samples obtained from 34 healthy male subjects selected on criteria typical for a phase I clinical trial across a wide age range (19–70 years).
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Pfaff T, Rhodes J, Bergmann M, Weinbauer GF
- HESI - Health and Environmental Sciences Institute
This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment-free period in control and 30, 60, and 180 mg/kg dose groups (n = 22/group).
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2011
Sasaki JC, Chapin RE, Hall DG, Breslin W, Moffit J, Saldutti L, ...
- HESI - Health and Environmental Sciences Institute
Testicular toxicity (TT) is a sporadic and challenging issue in pharmaceutical drug development.
ALTEX, 2013
Saldutti LP, Beyer BK, Breslin W, Brown TR, Chapin RE, Campion S, ...
- HESI - Health and Environmental Sciences Institute
To address the pressing need for better in vitro testicular toxicity models, a workshop sponsored by the International Life Sciences Institute (ILSI), the Health and Environmental Science Institute (HESI), and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), was held at the Mt. Washington ...
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