Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Solleveld HA, Portelli ST, Wier PJ
- HESI - Health and Environmental Sciences Institute
Idoxifene is a selective estrogen receptor modulator similar to tamoxifen but is no longer in pharmaceutical development due to adverse genitourinary effects in the clinic.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Stanislaus DJ, Wier PJ
- HESI - Health and Environmental Sciences Institute
Observations associated with drug-induced hyper- or hypoprolactinemia in rat toxicology studies may be similar and include increased ovarian weight due to increased presence of corpora lutea.
ALTEX, 2013
Saldutti LP, Beyer BK, Breslin W, Brown TR, Chapin RE, Campion S, ...
- HESI - Health and Environmental Sciences Institute
To address the pressing need for better in vitro testicular toxicity models, a workshop sponsored by the International Life Sciences Institute (ILSI), the Health and Environmental Science Institute (HESI), and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), was held at the Mt. Washington ...
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2011
Sasaki JC, Chapin RE, Hall DG, Breslin W, Moffit J, Saldutti L, ...
- HESI - Health and Environmental Sciences Institute
Testicular toxicity (TT) is a sporadic and challenging issue in pharmaceutical drug development.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Pfaff T, Rhodes J, Bergmann M, Weinbauer GF
- HESI - Health and Environmental Sciences Institute
This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment-free period in control and 30, 60, and 180 mg/kg dose groups (n = 22/group).
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Stewart J, Bickerton S, Betts CJ, Kirk S
- HESI - Health and Environmental Sciences Institute
Inhibin B was measured in plasma samples obtained from 34 healthy male subjects selected on criteria typical for a phase I clinical trial across a wide age range (19–70 years).
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