Development of Methods for a Tiered Approach to Assess Bioaccumulation of Chemicals Committee

Note: As of 2022, the former Animal Alternatives in ERA and Bioaccumulation Committees have merged to form the Next Generation ERA Committee

Mission Statement

The mission of the HESI Development of Methods for a Tiered Approach to Assess the Bioaccumulation of Chemicals Committee is to develop the tools needed for assessing the potential bioaccumulation of organic chemicals.

Working Groups

  • Bird Biotransformation and Toxicokinetics

    This working group is exploring the state of the science on biotransformation and toxicokinetics in birds. A literature review on bird bioaccumulation and biotransformation was funded by the committee and completed by Dr. Dave Kuo (City University of Hong Kong/Kuo Research and Consulting). This review involved evaluation of >550 peer-reviewed studies resulting in a database of >25,000 data entries on >700 organic compounds for nearly 500 wild and domestic bird species. Dr. Kuo is now leading the development of a manuscript to describe this effort, establish the state of the science in the field, and provide recommendations for future research.

  • Invertebrate Biotransformation and Toxicokinetics

    This working group is exploring the state of the science of biotransformation and toxicokinetics of organic chemicals in aquatic invertebrates. A literature compilation was conducted for 11 genera of invertebrates. The literature is currently being reviewed and biotransformation and toxicokinetics data are being extracted and stored in a database. This work, funded by the committee, is being conducted at the University of Hong Kong by two of Dr. Dave Kuo’s students.

  • Fish Biotransformation and Toxicokinetics

    The committee held an expert workshop in October 2019 on fish biotransformation in bioaccumulation, aimed at identifying short-, medium-, and long-term needs for research and coordination in this space. Approximately 35 experts from industry, academia, and government attended, and several publications and research programs will be initiated in the coming months. The committee will work to identify feasible next steps for additional data generation and analysis over the next year related to fish biotransformation and toxicokinetics. The group is preparing a manuscript on the current use and application of the in vitro test method.

HESI Staff

Steering Team

Committee Publications

Filter

Trophic Magnification Factors: Considerations of Ecology, Ecosystems, and Study Design

Integrated Environmental Assessment and Management, 2012

Borgå K, Kidd KA, Muir DC, Berglund O, Conder JM, Gobas FA, ...
  • HESI - Health and Environmental Sciences Institute

Recent reviews by researchers from academia, industry, and government have revealed that the criteria used by the Stockholm Convention on persistent organic pollutants under the United Nations Environment Programme are not always able to identify the actual bioaccumulative capacity of some substances, by use of chemical ...

Read more

The State of In Vitro Science for Use in Bioaccumulation Assessments for Fish

Environmental Toxicology and Chemistry, 2009

Weisbrod AV, Sahi J, Segner H, James MO, Nichols J, Schultz I, ...
  • HESI - Health and Environmental Sciences Institute

Through the concerted evaluations of thousands of commercial substances for the qualities of persistence, bioaccumulation, and toxicity as a result of the United Nations Environment Program's Stockholm Convention, it has become apparent that fewer empirical data are available on bioaccumulation than other endpoints and ...

Read more

Review of Laboratory-Based Terrestrial Bioaccumulation Assessment Approaches for Organic Chemicals: Current Status and Future Possibilities

Integrated Environmental Assessment and Management, 2015

Hoke R, Huggett D, Brasfield S, Brown B, Embry M, Fairbrother A, ...
  • HESI - Health and Environmental Sciences Institute

In the last decade, interest has been renewed in approaches for the assessment of the bioaccumulation potential of chemicals, principally driven by the need to evaluate large numbers of chemicals as part of new chemical legislation, while reducing vertebrate test organism use called for in animal welfare ...

Read more

Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Toxicological Sciences, 2018

Nichols J, Fay K, Bernhard MJ, Bischof I, Davis J, Halder M, Hu J, ...

The HESI Bioaccumulation Technical Committee completed a study highlighting several issues related to the demonstration of assay reliability and provided a template for evaluating other in vitro biotransformation assays. The results are published here.

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => Bioaccumulation
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Bioaccumulation
                        )

                )

            [paged] => 2
            [orderby] => title
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => Bioaccumulation
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Bioaccumulation
                        )

                )

            [paged] => 2
            [orderby] => title
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Bioaccumulation
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Bioaccumulation
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Bioaccumulation
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id)
					WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (24)
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_posts.post_title DESC
					LIMIT 6, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 3203
                    [post_author] => 6
                    [post_date] => 2016-06-17 13:29:33
                    [post_date_gmt] => 2016-06-17 18:29:33
                    [post_content] => 
                    [post_title] => Trophic Magnification Factors: Considerations of Ecology, Ecosystems, and Study Design
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => trophic-magnification-factors-considerations-of-ecology-ecosystems-and-study-design
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-17 13:29:33
                    [post_modified_gmt] => 2016-06-17 18:29:33
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3203
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 2683
                    [post_author] => 6
                    [post_date] => 2016-05-10 09:39:03
                    [post_date_gmt] => 2016-05-10 14:39:03
                    [post_content] => 
                    [post_title] => Toward Improved Models for Predicting Bioconcentration of Well-Metabolized Compounds by Rainbow Trout Using Measured Rates of In Vitro Intrinsic Clearance
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => toward-improved-models-for-predicting-bioconcentration-of-well-metabolized-compounds-by-rainbow-trout-using-measured-rates-of-in-vitro-intrinsic-clearance
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-10 09:39:03
                    [post_modified_gmt] => 2016-05-10 14:39:03
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2683
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3280
                    [post_author] => 6
                    [post_date] => 2016-06-20 22:48:43
                    [post_date_gmt] => 2016-06-21 03:48:43
                    [post_content] => 
                    [post_title] => The State of In Vitro Science for Use in Bioaccumulation Assessments for Fish
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-state-of-in-vitro-science-for-use-in-bioaccumulation-assessments-for-fish
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-20 22:48:43
                    [post_modified_gmt] => 2016-06-21 03:48:43
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3280
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 1966
                    [post_author] => 6
                    [post_date] => 2016-04-17 21:44:56
                    [post_date_gmt] => 2016-04-18 02:44:56
                    [post_content] => 
                    [post_title] => Review of Laboratory-Based Terrestrial Bioaccumulation Assessment Approaches for Organic Chemicals: Current Status and Future Possibilities
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => review-of-laboratory-based-terrestrial-bioaccumulation-assessment-approaches-for-organic-chemicals-current-status-and-future-possibilities
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-04-17 21:44:56
                    [post_modified_gmt] => 2016-04-18 02:44:56
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=1966
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 1963
                    [post_author] => 6
                    [post_date] => 2016-04-17 21:56:03
                    [post_date_gmt] => 2016-04-18 02:56:03
                    [post_content] => 
                    [post_title] => Review of Existing Terrestrial Bioaccumulation Models and Terrestrial Bioaccumulation Modeling Needs for Organic Chemicals
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => review-of-existing-terrestrial-bioaccumulation-models-and-terrestrial-bioaccumulation-modeling-needs-for-organic-chemicals
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2020-10-28 13:58:01
                    [post_modified_gmt] => 2020-10-28 13:58:01
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=1963
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 20732
                    [post_author] => 2
                    [post_date] => 2018-12-04 10:40:12
                    [post_date_gmt] => 2018-12-04 15:40:12
                    [post_content] => 
                    [post_title] => Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => reliability-of-in-vitro-methods-used-to-measure-intrinsic-clearance-of-hydrophobic-organic-chemicals-by-rainbow-trout-results-of-an-international-ring-trial
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2020-10-28 13:57:05
                    [post_modified_gmt] => 2020-10-28 13:57:05
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=20732
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 3203
            [post_author] => 6
            [post_date] => 2016-06-17 13:29:33
            [post_date_gmt] => 2016-06-17 18:29:33
            [post_content] => 
            [post_title] => Trophic Magnification Factors: Considerations of Ecology, Ecosystems, and Study Design
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => trophic-magnification-factors-considerations-of-ecology-ecosystems-and-study-design
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-06-17 13:29:33
            [post_modified_gmt] => 2016-06-17 18:29:33
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=3203
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 27
    [max_num_pages] => 5
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 3119414bfa6d8016ea206059ecdc2b00
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.