Development of Methods for a Tiered Approach to Assess Bioaccumulation of Chemicals Committee

Mission Statement

The mission of the HESI Development of Methods for a Tiered Approach to Assess the Bioaccumulation of Chemicals Committee is to develop the tools needed for assessing the potential bioaccumulation of organic chemicals.

Working Groups

  • Bird Biotransformation and Toxicokinetics

    This working group is exploring the state of the science on biotransformation and toxicokinetics in birds. A literature review on bird bioaccumulation and biotransformation was funded by the committee and completed by Dr. Dave Kuo (City University of Hong Kong/Kuo Research and Consulting). This review involved evaluation of >550 peer-reviewed studies resulting in a database of >25,000 data entries on >700 organic compounds for nearly 500 wild and domestic bird species. Dr. Kuo is now leading the development of a manuscript to describe this effort, establish the state of the science in the field, and provide recommendations for future research.

  • Invertebrate Biotransformation and Toxicokinetics

    This working group is exploring the state of the science of biotransformation and toxicokinetics of organic chemicals in aquatic invertebrates. A literature compilation was conducted for 11 genera of invertebrates. The literature is currently being reviewed and biotransformation and toxicokinetics data are being extracted and stored in a database. This work, funded by the committee, is being conducted at the University of Hong Kong by two of Dr. Dave Kuo’s students.

  • Fish Biotransformation and Toxicokinetics

    The committee held an expert workshop in October 2019 on fish biotransformation in bioaccumulation, aimed at identifying short-, medium-, and long-term needs for research and coordination in this space. Approximately 35 experts from industry, academia, and government attended, and several publications and research programs will be initiated in the coming months. The committee will work to identify feasible next steps for additional data generation and analysis over the next year related to fish biotransformation and toxicokinetics. The group is preparing a manuscript on the current use and application of the in vitro test method.

HESI Staff

Steering Team

Committee Publications

Filter

Practical Advice for Selecting or Determining Trophic Magnification Factors for Application Under the European Union Water Framework Directive

The HESI Bioaccumulation Committee has published practical advice for selecting or determining TMFs within the context of the European Union's Water Framework Directive. A decision tree based on a series of quality attributes for TMF is provided, along with several illustrative examples.

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Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

The HESI Bioaccumulation Technical Committee completed a study highlighting several issues related to the demonstration of assay reliability and provided a template for evaluating other in vitro biotransformation assays. The results are published here.

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Use of Terrestrial Field Studies in the Derivation of Bioaccumulation Potential of Chemicals

Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts.

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Review of Laboratory-Based Terrestrial Bioaccumulation Assessment Approaches for Organic Chemicals: Current Status and Future Possibilities

In the last decade, interest has been renewed in approaches for the assessment of the bioaccumulation potential of chemicals, principally driven by the need to evaluate large numbers of chemicals as part of new chemical legislation, while reducing vertebrate test organism use called for in animal welfare ...

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