Development of Methods for a Tiered Approach to Assess Bioaccumulation of Chemicals Committee

Note: As of 2022, the former Animal Alternatives in ERA and Bioaccumulation Committees have merged to form the Next Generation ERA Committee

Mission Statement

The mission of the HESI Development of Methods for a Tiered Approach to Assess the Bioaccumulation of Chemicals Committee is to develop the tools needed for assessing the potential bioaccumulation of organic chemicals.

Working Groups

  • Bird Biotransformation and Toxicokinetics

    This working group is exploring the state of the science on biotransformation and toxicokinetics in birds. A literature review on bird bioaccumulation and biotransformation was funded by the committee and completed by Dr. Dave Kuo (City University of Hong Kong/Kuo Research and Consulting). This review involved evaluation of >550 peer-reviewed studies resulting in a database of >25,000 data entries on >700 organic compounds for nearly 500 wild and domestic bird species. Dr. Kuo is now leading the development of a manuscript to describe this effort, establish the state of the science in the field, and provide recommendations for future research.

  • Invertebrate Biotransformation and Toxicokinetics

    This working group is exploring the state of the science of biotransformation and toxicokinetics of organic chemicals in aquatic invertebrates. A literature compilation was conducted for 11 genera of invertebrates. The literature is currently being reviewed and biotransformation and toxicokinetics data are being extracted and stored in a database. This work, funded by the committee, is being conducted at the University of Hong Kong by two of Dr. Dave Kuo’s students.

  • Fish Biotransformation and Toxicokinetics

    The committee held an expert workshop in October 2019 on fish biotransformation in bioaccumulation, aimed at identifying short-, medium-, and long-term needs for research and coordination in this space. Approximately 35 experts from industry, academia, and government attended, and several publications and research programs will be initiated in the coming months. The committee will work to identify feasible next steps for additional data generation and analysis over the next year related to fish biotransformation and toxicokinetics. The group is preparing a manuscript on the current use and application of the in vitro test method.

HESI Staff

Steering Team

Committee Publications

Filter

Guidance for Evaluating In Vivo Fish Bioaccumulation Data

Integrated Environmental Assessment and Management, 2008

Parkerton TF, Arnot JA, Weisbrod AV, Russom C, Hoke RA, ...
  • HESI - Health and Environmental Sciences Institute

Currently, the laboratory-derived fish bioconcentration factor (BCF) serves as one of the primary data sources used to assess the potential for a chemical to bioaccumulate.

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The State of In Vitro Science for Use in Bioaccumulation Assessments for Fish

Environmental Toxicology and Chemistry, 2009

Weisbrod AV, Sahi J, Segner H, James MO, Nichols J, Schultz I, ...
  • HESI - Health and Environmental Sciences Institute

Through the concerted evaluations of thousands of commercial substances for the qualities of persistence, bioaccumulation, and toxicity as a result of the United Nations Environment Program's Stockholm Convention, it has become apparent that fewer empirical data are available on bioaccumulation than other endpoints and ...

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Protein and Lipid Binding Parameters in Rainbow Trout (Oncorhynchus Mykiss) Blood And Liver Fractions to Extrapolate From an In Vitro Metabolic Degradation Assay to In Vivo Bioaccumulation Potential of Hydrophobic Organic Chemicals

Chemical Research in Toxicology, 2011

Escher BI, Cowan-Ellsberry CE, Dyer S, Embry MR, Erhardt S, ...
  • HESI - Health and Environmental Sciences Institute

Binding of hydrophobic chemicals to colloids such as proteins or lipids is difficult to measure using classical microdialysis methods due to low aqueous concentrations, adsorption to dialysis membranes and test vessels, and slow kinetics of equilibration.

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Trophic Magnification Factors: Considerations of Ecology, Ecosystems, and Study Design

Integrated Environmental Assessment and Management, 2012

Borgå K, Kidd KA, Muir DC, Berglund O, Conder JM, Gobas FA, ...
  • HESI - Health and Environmental Sciences Institute

Recent reviews by researchers from academia, industry, and government have revealed that the criteria used by the Stockholm Convention on persistent organic pollutants under the United Nations Environment Programme are not always able to identify the actual bioaccumulative capacity of some substances, by use of chemical ...

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Comparing Laboratory‐and Field‐Measured Biota–Sediment Accumulation Factors

Integrated Environmental Assessment and Management, 2012

Burkhard LP, Arnot JA, Embry MR, Farley KJ, Hoke RA, Kitano M, ...
  • HESI - Health and Environmental Sciences Institute

Standardized laboratory protocols for measuring the accumulation of chemicals from sediments are used in assessing new and existing chemicals, evaluating navigational dredging materials, and establishing site-specific biota-sediment accumulation factors (BSAFs) for contaminated sediment sites.

Read more

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