Critical Reviews in Toxicology, 2013
Scholz S, Renner P, Belanger SE, Busquet F, Davi R, Demeneix BA, ...
- HESI - Health and Environmental Sciences Institute
Endocrine disruption is considered a highly relevant hazard for environmental risk assessment of chemicals, plant protection products, biocides and pharmaceuticals.
Environmental Toxicology and Chemistry, 2018
Norberg‐King TJ, Embry MR, Belanger SE, Braunbeck T, Butler JD, ...
HESI's Animal Alternatives in ERA Committee published tools and concepts for effluent toxicity assessment in an issue of SETAC's Environmental Toxicology and Chemistry. The publication discusses a suite of strategies that can be used in a weight of evidence approach to reduce reliance on in vivo fish tests as part of an ...
Science of the Total Environment, 2019
Kienzler A, Bopp S, Halder M, Embry MR, Worth A
There is growing evidence that single substances present below their individual thresholds of effect may still contribute to combined effects. Here, the possible use of ecotoxicological threshold concentrations of no concern (i.e. 5th percentile of statistical distribution of ecotoxicological values) is investigated to ...
Regulatory Toxicology and Pharmacology, 2021
Belanger SE, Beasley A, Brill JL, Krailler J, Connors KA, Carr GJ, ...
Derivation of Predicted No Effect Concentrations (PNECs) for aquatic systems is the primary deterministic form of hazard extrapolation used in environmental risk assessment. Depending on the data availability, different regulatory jurisdictions apply application factors (AFs) to the most sensitive measured endpoint to ...
Environmental Toxicology and Chemistry, 2019
Connors KA, Beasley A, Barron MG, Belanger SE, Bonnell M, ...
The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.
Chemosphere, 2021
Brill JL, Belanger SE, Barron MG, Beasley A, Connors KA, Embry M, ...
Algal toxicity studies are required by regulatory agencies for a variety of purposes including classification and labeling and environmental risk assessment of chemicals. Algae are also frequently the most sensitive taxonomic group tested. Acute to chronic ratios (ACRs) have been challenging to derive for algal species ...
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