The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.
Animal Alternatives in Environmental Risk Assessment Committee
HESI's Animal Alternatives in Environmental Risk Assessment Committee
To ensure the development of a sound technical basis for alternative test methods as a means to reduce, refine, or replace standard ecotoxicity test procedures around the globe.
The committee aims to provide a forum to coordinate the debates and best emerging practices of the alternatives and animal model development sciences to meet existing hazard assessment, effluent assessment, risk assessment, classification and labeling, and other regulatory needs.
Scott Belanger, PhD
The Procter & Gamble Company
Thomas Braunbeck, PhD
University of Heidelberg
Members and Fact Sheet
HESI’s Animal Alternatives in ERA Committee published tools and concepts for effluent toxicity assessment in an issue of SETAC’s Environmental Toxicology and Chemistry. The publication discusses a suite of strategies that can be used in a weight of evidence approach to reduce reliance on in vivo fish tests as part of an effluent evaluation “toolbox.”
The threshold of toxicological concern (TTC) concept is well established for assessing human safety of food-contact substances and has been reapplied for a variety of endpoints, including carcinogenicity, teratogenicity, and reproductive toxicity.
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs.
Endocrine disruption is considered a highly relevant hazard for environmental risk assessment of chemicals, plant protection products, biocides and pharmaceuticals.