Animal Alternatives in Environmental Risk Assessment Committee

Mission Statement

To ensure the development of a sound technical basis for alternative test methods as a means to reduce, refine, or replace standard ecotoxicity test procedures around the globe.

The committee aims to provide a forum to coordinate the debates and best emerging practices of the alternatives and animal model development sciences to meet existing hazard assessment, effluent assessment, risk assessment, classification and labeling, and other regulatory needs.

HESI Staff

Committee Publications

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Application of New Statistical Distribution Approaches for Environmental Mixture Risk Assessment: A Case Study

There is growing evidence that single substances present below their individual thresholds of effect may still contribute to combined effects. Here, the possible use of ecotoxicological threshold concentrations of no concern (i.e. 5th percentile of statistical distribution of ecotoxicological values) is investigated to ...

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Mode of Action (MOA) Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification

Multiple modes of action (MOA) frameworks have been developed in aquatic ecotoxicology, mainly based on fish toxicity. These frameworks provide information on a key determinant of chemical toxicity, but the MOA categories and level of specificity remain unique to each of the classification schemes. This study aimed to develop a ...

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Creation of a Curated Aquatic Toxicology Database: EnviroTox

The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.

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An International Perspective on the Tools and Concepts for Effluent Toxicity Assessments in the Context of Animal Alternatives: Reduction in Vertebrate Use

HESI's Animal Alternatives in ERA Committee published tools and concepts for effluent toxicity assessment in an issue of SETAC's Environmental Toxicology and Chemistry. The publication discusses a suite of strategies that can be used in a weight of evidence approach to reduce reliance on in vivo fish tests as part of an ...

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Investigating Alternatives to the Fish Early-Life Stage Test: A Strategy for Discovering and Annotating Adverse Outcome Pathways for Early Fish Development

The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs.

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