Risk Assessment in the 21st Century (RISK21) Committee

Mission Statement

The committee’s mission is to promote a transparent, purpose-driven, structured approach to risk assessment based on key principles, including problem formulation, tiered integration of both hazard and exposure at each step, and fit for purpose.

Version 2.0 of the RISK21 webtool is now available. To access the RISK21 webtool, please visit risk21.org.

 

Working Groups

  • Brazil Pesticide Use Information Tool

    The Committee contracted out the development of a database of information necessary to estimate pesticide exposure (and obtain parameters for exposure models) in Brazil. Pesticide use and application information are being extracted from the Brazilian Health Regulatory Agency (ANVISA) monographs and from Agrofit, Brazil’s pesticide registration tool, and pulled into an easily searchable, publicly accessible database.

    A project advisory team is monitoring and supporting the project, which is expected to be completed in the first quarter of 2023.

  • Argentina Pesticide Residue Information Tool

    A tool developed to inform pesticide residues in food in Argentina was funded and developed for SENASA. It resulted from a partnership between HESI, Buenos Aires and Austral Universities, and SENASA. A manuscript co-authored by all partners and featuring this effort will be developed in the coming year.

  • Pesticide Labeling Harmonization

    Initiated discussion to explore how to better harmonize pesticide labels by:

    • Identifying the needs across various countries/regions
    • Communicating ongoing work in this space (e.g., smart labels, e-labels, etc.) within and outside of OECD (webinar will be scheduled in Q4 2022 to share updates)
    • Working to identify potential partnerships
  • RISK21 Toolkit Update

    Discussions have been initiated to improve both the RAFT tool and RISK21 matrix and make them more user-friendly.

HESI Staff

Committee Events

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Committee Publications

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Risk Assessment in the 21st Century: Roadmap and Matrix

Critical Reviews in Toxicology, 2014

Embry MR, Bachman AN, Bell DR, Boobis AR, Cohen SM, Dellarco M, ...
  • HESI - Health and Environmental Sciences Institute

The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix.

Read more

A 21st Century Roadmap for Human Health Risk Assessment

Critical Reviews in Toxicology, 2014

Pastoor TP, Bachman AN, Bell DR, Cohen SM, Dellarco M, ...
  • HESI - Health and Environmental Sciences Institute

The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government ...

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The Use of Mode of Action Information in Risk Assessment: Quantitative Key Events/Dose-Response Framework for Modeling the Dose-Response for Key Events

Critical Reviews in Toxicology, 2014

Simon TW, Simons SS, Preston RJ, Boobis AR, Cohen SM, Doerrer NG, ...
  • HESI - Health and Environmental Sciences Institute

The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in silico) to advance the next-generation of chemical risk assessments.

Read more

Use of the RISK21 Roadmap and Matrix: Human Health Risk Assessment of the Use of a Pyrethroid in Bed Netting

Critical Reviews in Toxicology , 2015

Doe JE, Lander DR, Doerrer NG, Heard N, Hines RN, Lowit AB, ...
  • HESI - Health and Environmental Sciences Institute

The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety.

Read more

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