Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Can We Panelize Seizure?

Toxicological Sciences, 2020

Roberts R, Authier S, Mellon D, Morton M, Suzuki I, Tjalkens RB, ...

Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays and increased costs. Current detection methods rely on observations made in in vivo studies intended to support clinical trials, such as tremors or other abnormal movements. These signs ...

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Can Nonclinical Repolarization Assays Predict the Results of Clinical Thorough QT Studies? Results from a Research Consortium.

British Journal of Pharmacology, 2017

Park EJ, Gintant GA, Bi D, Kozeli D, Pettit SD, Pierson JB, ...
  • HESI - Health and Environmental Sciences Institute

The strengths and limitations of three nonclinical repolarization assays used to define the risk of clinical drug-induced delayed ventricular repolarization (a surrogate marker of the rare but potentially lethal arrhythmia Torsades de Pointes) were compared during a retrospective analysis of an anonymized database of 150 ...

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Birth Control in Clinical Trials: Industry Survey of Current Use Practices, Governance, and Monitoring

Therapeutic Innovation & Regulatory Science, 2016

Stewart J, Breslin WJ, Beyer BK, Chadwick K, De Schaepdrijver L, ...
  • HESI - Health and Environmental Sciences Institute

The Health and Environmental Sciences Institute (HESI) Developmental and Reproductive Toxicology Technical Committee sponsored a pharmaceutical industry survey on current industry practices for contraception use during clinical trials.

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Biological Qualification of Biomarkers of Chemical-Induced Renal Toxicity in Two Strains of Male Rat

Toxicological Sciences, 2011

Harpur E, Ennulat D, Hoffman D, Betton G, Gautier JC, Riefke B, ...
  • HESI - Health and Environmental Sciences Institute

This study reports the evaluation of four urinary biomarkers of renal toxicity, α-glutathione-S-transferase (α-GST), μ-GST, clusterin, and renal papillary antigen-1 (RPA-1), in male Sprague-Dawley and Han-Wistar rats given cisplatin, gentamicin, or N-phenylanthranilic acid (NPAA).

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Health and Environmental Sciences Institute (HESI)

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