Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies

Neuromethods, 2019

He Z, Panos J, Raymick J, Konak T, Cui L, Miller DB, ...

Sampling and analysis of cerebrospinal fluid (CSF) is a common clinical practice used in the diagnosis, treatment, and prevention of neurological diseases. A similar interest is the sampling of CSF from rats to bridge the gap between bench-to-bedside work and to foster the development of new CSF biomarkers for clinical use. Here, ...

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Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites

Toxicological Sciences, 2019

Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, ...
  • HESI - Health and Environmental Sciences Institute

A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.

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Improving Attribution of Adverse Events in Oncology Clinical Trials

Cancer Treatment Reviews, 2019

George GC, Barata PC, Campbell A, Chen A, Cortes JE, Hyman DM, ...
  • HESI - Health and Environmental Sciences Institute

Attribution of adverse events (AEs) is critical to oncology drug development and the regulatory process. However, processes for determining the causality of AEs are often sub-optimal, unreliable, and inefficient. Thus, a toxicity-attribution workshop was conducted in Silver Spring, MD to develop guidance for improving ...

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Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications

Drug Metabolism and Disposition, 2019

Neal-Kluever A, Fisher J, Grylack L, Kakiuchi-Kiyota S, ...

This review is part of a multisector collaborative research effort coordinated by the HESI Developmental and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population (De Schaepdrijver et ...

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A Comparison of Transgenic Rodent Mutation and In Vivo Comet Assay Responses for 91 Chemicals

Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2019

Kirkland D, Levy DD, LeBaron MJ, Aardema MJ, Beevers C, Bhalli J, ...

Whilst the TGR and comet assays are available for measuring genotoxic effects in multiple rodent tissues, there has been no systematic comparison of their performance in detecting genotoxicity per se. A working group of the Genetic Toxicology Technical Committee (GTTC), part of the Health and Environmental Sciences Institute ...

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