Toxicological Sciences, 2019
Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, ...
- HESI - Health and Environmental Sciences Institute
A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Cline JM
- HESI - Health and Environmental Sciences Institute
This review provides a summary of the normal biology, development, and morphology of the breast in nonhuman primates (macaques), and of the major published work addressing hormonally-induced changes in the breast of these animals.
Toxicological Sciences, 2006
Holsapple MP, Jones D, Kawabata TT, Kimber I, Sarlo K, ...
- HESI - Health and Environmental Sciences Institute
Acute and repeat dose inhalation studies have been an important part of the safety assessment of drugs, chemicals, and other products throughout the world for many years.
Reproductive Toxicology, 2015
Thompson KE, Rayhon SL, Bailey G, Delille P, McNerney ME
- HESI - Health and Environmental Sciences Institute
Risk assessment for indirect exposure to small molecule pharmaceuticals in semen to the conceptus has traditionally been handled by calculations based on assumptions that any embryo-fetal exposure would be secondary to maternal absorption and redistribution.
Reproductive Toxicology, 2014
Breslin WJ, Hilbish KG, Page TJ, Coutant DE
- HESI - Health and Environmental Sciences Institute
Studies were conducted in New Zealand White rabbits to assess the seminal transfer, vaginal absorption, and placental transfer of a therapeutic monoclonal antibody (T-IgG4).
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Moffit JS, Her LS, Mineo AM, Knight BL, Phillips JA, Thibodeau MS
- HESI - Health and Environmental Sciences Institute
Although histopathology is considered the gold standard for assessing testicular toxicity in the nonclinical setting, identification of noninvasive biomarkers for testicular injury are desirable to improve safety monitoring capabilities for clinical trials.
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