Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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The Use of Mode of Action Information in Risk Assessment: Quantitative Key Events/Dose-Response Framework for Modeling the Dose-Response for Key Events

Critical Reviews in Toxicology, 2014

Simon TW, Simons SS, Preston RJ, Boobis AR, Cohen SM, Doerrer NG, ...
  • HESI - Health and Environmental Sciences Institute

The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in silico) to advance the next-generation of chemical risk assessments.

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The T-Cell-Dependent Antibody Response Assay in Nonclinical Studies of Pharmaceuticals and Chemicals: Study Design, Data Analysis, Interpretation

Regulatory Toxicology and Pharmacology, 2014

Lebrec H, Molinier B, Boverhof D, Collinge M, Freebern W, ...
  • HESI - Health and Environmental Sciences Institute

The T-cell-dependent antibody response (TDAR) assay is a measure of immune function that is dependent upon the effectiveness of multiple immune processes, including antigen uptake and presentation, T cell help, B cell activation, and antibody production.

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The State of In Vitro Science for Use in Bioaccumulation Assessments for Fish

Environmental Toxicology and Chemistry, 2009

Weisbrod AV, Sahi J, Segner H, James MO, Nichols J, Schultz I, ...
  • HESI - Health and Environmental Sciences Institute

Through the concerted evaluations of thousands of commercial substances for the qualities of persistence, bioaccumulation, and toxicity as a result of the United Nations Environment Program's Stockholm Convention, it has become apparent that fewer empirical data are available on bioaccumulation than other endpoints and ...

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The Rodent Estrous Cycle: Characterization of Vaginal Cytology and Its Utility in Toxicological Studies

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007

Goldman JM, Murr AS, Cooper RL
  • HESI - Health and Environmental Sciences Institute

While an evaluation of the estrous cycle in laboratory rodents can be a useful measure of the integrity of the hypothalamic-pituitary-ovarian reproductive axis, it can also serve as a way of insuring that animals exhibiting abnormal cycling patterns are disincluded from a study prior to exposure to a test compound.

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