Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Assessment of Cervical Passage of Vital Dyes in Pregnant, Nonpregnant, and Mated Rat and Mice

Reproductive Toxicology, 2015

Thompson KE, Rayhon SL, Bailey G, Delille P, McNerney ME
  • HESI - Health and Environmental Sciences Institute

Risk assessment for indirect exposure to small molecule pharmaceuticals in semen to the conceptus has traditionally been handled by calculations based on assumptions that any embryo-fetal exposure would be secondary to maternal absorption and redistribution.

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Assessing the Potential to Induce Respiratory Hypersensitivity

Toxicological Sciences, 2006

Holsapple MP, Jones D, Kawabata TT, Kimber I, Sarlo K, ...
  • HESI - Health and Environmental Sciences Institute

Acute and repeat dose inhalation studies have been an important part of the safety assessment of drugs, chemicals, and other products throughout the world for many years.

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Assessing the Mammary Gland of Nonhuman Primates: Effects of Endogenous Hormones and Exogenous Hormonal Agents and Growth Factors

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007

Cline JM
  • HESI - Health and Environmental Sciences Institute

This review provides a summary of the normal biology, development, and morphology of the breast in nonhuman primates (macaques), and of the major published work addressing hormonally-induced changes in the breast of these animals.

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Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites

Toxicological Sciences, 2019

Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, ...
  • HESI - Health and Environmental Sciences Institute

A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.

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Approaches to Dose Finding in Neonates, Illustrating the Variability Between Neonatal Drug Development Programs

Pharmaceutics, 2020

Van den Anker JN, McCune S, Annaert P, Baer GR, Mulugeta Y, ...
  • HESI - Health and Environmental Sciences Institute

Drug dosing in neonates should be based on integrated knowledge concerning the disease to be treated, the physiological characteristics of the neonate, and the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. It is critically important that all sources of information be leveraged to optimize dose selection for ...

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