Toxicological Sciences, 2009
North CM, Kim BS, Snyder N, Crawford RB, Holsapple MP, ...
- HESI - Health and Environmental Sciences Institute
Suppression of humoral immune responses by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been well established to require the aryl hydrocarbon receptor; however, the downstream mechanisms for this immunotoxic response remain poorly understood.
Frontiers in Big Data, 2019
Li HH, Yauk C, Chen R, Hyduke DR, Williams A, Frötschl R, ...
Genotoxicity testing is an essential component of the safety assessment paradigm required by regulatory agencies world-wide for analysis of drug candidates, and environmental and industrial chemicals. Current genotoxicity testing batteries feature a high incidence of irrelevant positive findings – particularly for in ...
Toxicological Sciences, 2011
Kim JH, Scialli AR
- HESI - Health and Environmental Sciences Institute
Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women.
Critical Reviews in Toxicology, 2006
Barton HA, Pastoor TP, Baetcke K, Chambers JE, Diliberto J, ...
- HESI - Health and Environmental Sciences Institute
A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals.
Environmental Health Perspectives, 2006
Butenhoff JL, Olsen GW, Pfahles-Hutchens A
- HESI - Health and Environmental Sciences Institute
Perfluorooctanesulfonate and its salts (PFOS) are derived from perfluorooctanesulfonyl fluoride, the basic chemical building block for many sulfonyl-based fluorochemicals used as surfactants and for their repellent properties.
Disease Models & Mechanisms, 2022
Sarah Campion, Amy Inselman, Belinda Hayes, Costanza Casiraghi, ...
Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, perinatal hypoxic–ischemic ...
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