Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Comparison Between Male and Female Sprague-Dawley Rats in the Response of Urinary Biomarkers to Injury Induced by Gentamicin

Toxicologic Pathology, 2014

Gautier JC, Gury T, Guffroy M, Masson R, Khan-Malek R, Hoffman D, ...
  • HESI - Health and Environmental Sciences Institute

Differences were examined between male and female Sprague-Dawley rats in the response of 16 urinary biomarkers (measured using several assay platforms) to renal injury produced by gentamicin administered subcutaneously for 10 days at a dosage of 75 mg/kg.

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Comparing Rat and Rabbit Embryo-Fetal Developmental Toxicity Data for 379 Pharmaceuticals: On Systemic Dose and Developmental Effects

Critical Reviews in Toxicology , 2016

Theunissen PT, Beken S, Beyer B, Breslin WJ, Cappon GD, Chen CL, ...

A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental lowest adverse effect level (dLOAEL). For the vast ...

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Comparing Laboratory‐and Field‐Measured Biota–Sediment Accumulation Factors

Integrated Environmental Assessment and Management, 2012

Burkhard LP, Arnot JA, Embry MR, Farley KJ, Hoke RA, Kitano M, ...
  • HESI - Health and Environmental Sciences Institute

Standardized laboratory protocols for measuring the accumulation of chemicals from sediments are used in assessing new and existing chemicals, evaluating navigational dredging materials, and establishing site-specific biota-sediment accumulation factors (BSAFs) for contaminated sediment sites.

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Comparing Laboratory and Field Measured Bioaccumulation Endpoints

Integrated Environmental Assessment and Management, 2012

Burkhard LP, Arnot JA, Embry MR, Farley KJ, Hoke RA, Kitano M, ...
  • HESI - Health and Environmental Sciences Institute

An approach for comparing laboratory and field measures of bioaccumulation is presented to facilitate the interpretation of different sources of bioaccumulation data.

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Comparing BMD-Derived Genotoxic Potency Estimations Across Variants of the Transgenic Rodent Gene Mutation Assay

Environmental and Molecular Mutagenesis, 2017

JW Wills, GE Johnson, HL Battaion, W Slob, PA White
  • HESI - Health and Environmental Sciences Institute

There is growing interest in quantitative analysis of in vivo genetic toxicity dose-response data, and use of point-of-departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, ...

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Comparative Organ System Development: Introduction

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2003

Hurtt ME, Sandler JD
  • HESI - Health and Environmental Sciences Institute

It is well known that development continues postnatally in both humans and animals.

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