Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Current and Future Needs for Developmental Toxicity Testing

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2011

Makris SL, Kim JH, Ellis A, Faber W, Harrouk W, Lewis JM, Paule MG, ...
  • HESI - Health and Environmental Sciences Institute

A review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer ...

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Current and Future Methods for Evaluating the Allergenic Potential of Proteins: International Workshop Report 23–25 October 2007

Food and Chemical Toxicology, 2008

Thomas K, Herouet-Guicheney C, Ladics G, McClain S, MacIntosh S, ...
  • HESI - Health and Environmental Sciences Institute

The International Life Science Institute’s Health and Environmental Sciences Institute’s Protein Allergenicity Technical Committee hosted an international workshop October 23–25, 2007, in Nice, France, to review and discuss existing and emerging methods and techniques for improving the current ...

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Current and Future Applications of Toxicogenomics: Results Summary of a Survey From the HESI Genomics State of Science Subcommittee

Environmental Health Perspectives, 2010

Pettit S, des Etages SA, Mylecraine L, Snyder R, Fostel J, ...
  • HESI - Health and Environmental Sciences Institute

In spite of the application of toxicogenomic (TGx) data to the field of toxicology for the past 10 years, the broad implementation and full impact of TGx for chemical and drug evaluation to improve decision making within organizations and by policy makers has not been achieved.

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Cross-Site Comparison Of Gene Expression Data Reveals High Similarity

Environmental Health Perspectives, 2004

Chu TM, Deng S, Wolfinger R, Paules RS, Hamadeh HK
  • HESI - Health and Environmental Sciences Institute

Consistency and coherence of gene expression data across multiple sites depends on several factors such as platform (oligo, cDNA, etc.), environmental conditions at each laboratory, and data quality.

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Cross-Site and Cross-Platform Variability of Automated Patch Clamp Assessments of Drug Effects on Human Cardiac Currents in Recombinant Cells

Nature Scientific Reports, 2020

Kramer J, Himmel HM, Lindqvist A, Stoelzle-Feix S, Chaudhary KW, ...

Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability of IC50 values characterizing drug block ...

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