Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2007
Thybaud V, Aardema M, Casciano D, Dellarco V, Embry MR, ...
- HESI - Health and Environmental Sciences Institute
In vitro genotoxicity assays are often used to screen and predict whether chemicals might represent mutagenic and carcinogenic risks for humans.
Toxicological Sciences, 2018
Nichols J, Fay K, Bernhard MJ, Bischof I, Davis J, Halder M, Hu J, ...
The HESI Bioaccumulation Technical Committee completed a study highlighting several issues related to the demonstration of assay reliability and provided a template for evaluating other in vitro biotransformation assays. The results are published here.
Regulatory Toxicology and Pharmacology, 2020
Gintant G, Kaushik EP, Feaster T, Stoelzle-Feix S, Kanda Y, ...
- HESI - Health and Environmental Sciences Institute
Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the ability of hSC-CMs to detect drug-induced delayed ...
Environmental Health Perspectives, 1996
Reif JS, Hatch MC, Bracken M, Holmes LB, Schwetz BA, Singer PC
- HESI - Health and Environmental Sciences Institute
Recent epidemiologic studies have reported associations between the consumption of chlorinated drinking water and reproductive and developmental effects.
2010
Cooper RL, Doerrer NG
- HESI - Health and Environmental Sciences Institute
This chapter was published in Comprehensive Toxicology.
Toxicological Sciences, 2005
Thomas K, Sayre P
- HESI - Health and Environmental Sciences Institute
Nanotechnology has the potential to dramatically improve the effectiveness of a number of existing consumer and industrial products and could have a substantial impact on the development of new products ranging from disease diagnosis and treatment to environmental remediation.
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