Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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RATEmiRs: The Rat Atlas of Tissue-Specific and Enriched miRNAs Database

BMC Genomics, 2018

Bushel PR, Caiment F, Wu H, O'Lone R, Day F, Calley J, Smith A, ...
  • HESI - Health and Environmental Sciences Institute

MicroRNAs (miRNAs) regulate gene expression and have been targeted as indicators of environmental/toxicologic stressors. Using the data from our deep sequencing of miRNAs in an extensive sampling of rat tissues, we developed a database called RATEmiRs for the Rat Atlas of Tissue-specific and Enriched miRNAs to allow users to ...

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Rechanneling the Cardiac Proarrhythmia Safety Paradigm: A Meeting Report From the Cardiac Safety Research Consortium

American Heart Journal, 2014

Sager PT, Gintant G, Turner JR, Pettit S, Stockbridge N
  • HESI - Health and Environmental Sciences Institute

This white paper provides a summary of a scientific proposal presented at a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/Food and Drug Administration–sponsored Think Tank, held at Food and Drug Administration's White Oak facilities, Silver Spring, MD, on July 23, 2013, with the intention ...

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Recommendations for Conducting the Rodent Erythrocyte Pig‐a Assay: A Report from the HESI GTTC Pig‐a Workgroup

Environmental and Molecular Mutagenesis, 2021

Dertinger SD, Bhalli JA, Roberts DJ, Stankowski LF, Gollapudi BB, ...

The rodent Pig‐a assay is a flow cytometric, phenotype‐based method used to measure in vivo somatic cell mutation. An Organization for Economic Co‐operation and Development (OECD) test guideline is currently being developed to support routine use of the assay for regulatory purposes (OECD project number ...

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Regulatory Aspects on the Use of Fish Embryos in Environmental Toxicology

Integrated Environmental Assessment and Management, 2010

Halder M, Léonard M, Iguchi T, Oris JT, Ryder K, Belanger SE, ...
  • HESI - Health and Environmental Sciences Institute

Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management of chemicals and wastewater discharges.

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Relationships Between p53 Status, Apoptosis and Induction of Micronuclei in Different Human and Mouse Cell Lines In Vitro: Implications for Improving Existing Assays

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015

Whitwell J, Smith R, Jenner K, Lyon H, Wood D, Clements J, ...
  • HESI - Health and Environmental Sciences Institute

Accumulated evidence has shown that in vitro mammalian cell genotoxicity assays produce high frequencies of "misleading" positive results, i.e. predicted hazard is not confirmed in in vivo and/or carcinogenicity studies [1], raising the question of relevance to human risk assessment.

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