Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Development and Validation of a High-Throughput Transcriptomic Biomarker to Address 21st Century Genetic Toxicology Needs

Proceedings of the National Academy of Sciences, 2017

Li HH, Chen R, Hyduke DR, Williams A, Frötschl R, ...

Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive findings (i.e., positive ...

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Developing a Framework for Assessing Chemical Respiratory Sensitization: A Workshop Report

Regulatory Toxicology and Pharmacology, 2016

North CM, Ezendam J, Hotchkiss JA, Maier C, Aoyama K, Enoch S, ...

Respiratory tract sensitization can have significant acute and chronic health implications. While induction of respiratory sensitization is widely recognized for some chemicals, validated standard methods or frameworks for identifying and characterizing the hazard are not available. A workshop on assessment of ...

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