Human and Experimental Toxicology, 2002
Holsapple MP
- HESI - Health and Environmental Sciences Institute
A workshop entitled 'Developmental Immunotoxicology and Risk Assessment' was held on 12-13 June 2001, in Washington, DC.
Toxicology, 2003
Holsapple MP
- HESI - Health and Environmental Sciences Institute
There are currently no validated or widely accepted methods for evaluating the effects of a chemical on the developing immune system.
Journal of Immunotoxicology, 2012
Collinge M, Burns-Naas LA, Chellman GJ, Kawabata TT, Komocsar WJ, ...
- HESI - Health and Environmental Sciences Institute
The development and regulatory approval of immunomodulatory pharmaceuticals to treat many human diseases has increased significantly over the last two decades.
Cytokine, 2020
Vessillier S, Fort M, O'Donnell L, Hinton H, Nadwodny K, ...
Author links open overlay Immunomodulatory therapeutics such as monoclonal antibodies (mAb) carry an inherent risk of undesired immune reactions. One such risk is cytokine release syndrome (CRS), a rapid systemic inflammatory response characterized by the secretion of pro-inflammatory cytokines from immune cells. It is ...
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Hoyer PB, Sipes IG
- HESI - Health and Environmental Sciences Institute
The occupational chemical 4-vinylcyclohexene (VCH) has been shown to cause destruction of small pre-antral follicles in ovaries of mice.
Journal of Pharmacological and Toxicological Methods, 2024
De Alwis et al.
The Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee designed and created a publicly accessible database with an initial set of 128 pharmacologically defined pharmaceutical agents, many with known cardiotoxic properties.
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