Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Assessment of Cervical Passage of Vital Dyes in Pregnant, Nonpregnant, and Mated Rat and Mice

Reproductive Toxicology, 2015

Thompson KE, Rayhon SL, Bailey G, Delille P, McNerney ME
  • HESI - Health and Environmental Sciences Institute

Risk assessment for indirect exposure to small molecule pharmaceuticals in semen to the conceptus has traditionally been handled by calculations based on assumptions that any embryo-fetal exposure would be secondary to maternal absorption and redistribution.

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Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward

Toxicological Sciences, 2015

Roberts RA, Aschner M, Calligaro D, Guilarte TR, Hanig JP, ...

Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from ...

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Use of Terrestrial Field Studies in the Derivation of Bioaccumulation Potential of Chemicals

Integrated Environmental Assessment and Management, 2015

van den Brink NW, Arblaster JA, Bowman SR, Conder JM, Elliott JE, ...
  • HESI - Health and Environmental Sciences Institute

Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts.

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HESI/FDA Workshop on Immunomodulators and Cancer Risk Assessment: Building Blocks for a Weight-of-Evidence Approach

Regulatory Toxicology and Pharmocology, 2015

Lebrec H, Brennan FR, Haggerty H, Herzyk D, Kamperschroer C, ...

Profound immunosuppression (e.g., AIDS, transplant therapy) is epidemiologically associated with an increased cancer risk, and often with oncogenic viruses. It is currently unclear how broadly this association translates to therapeutics that modulate immunity. A workshop co-sponsored by the FDA and HESI examined how ...

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