Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Inter‐Laboratory Control Data for Reproductive Endpoints Required in the OPPTS 870.3800/OECD 416 Reproduction and Fertility Test

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2009

Marty MS, Allen B, Chapin RE, Cooper R, Daston GP, Flaws JA, ...
  • HESI - Health and Environmental Sciences Institute

The U.S. EPA revised the Reproduction and Fertility Effects Test Guideline (OPPTS 870.3800/OECD 416) in 1998, adding numerous endpoints in an effort to incorporate new methodologies, improve the sensitivity for detecting reproductive toxicants, and more efficiently utilize study animals.

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Intra- and Interlaboratory Reliability of a Cryopreserved Trout Hepatocyte Assay for the Prediction of Chemical Bioaccumulation Potential

Environmental Science & Technology, 2014

Fay KA, Mingoia RT, Goeritz I, Nabb DL, Hoffman AD, Ferrell BD, ...
  • HESI - Health and Environmental Sciences Institute

Measured rates of intrinsic clearance determined using cryopreserved trout hepatocytes can be extrapolated to the whole animal as a means of improving modeled bioaccumulation predictions for fish.

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Investigating Alternatives to the Fish Early-Life Stage Test: A Strategy for Discovering and Annotating Adverse Outcome Pathways for Early Fish Development

Environmental Toxicology and Chemistry, 2014

Villeneuve D, Volz DC, Embry MR, Ankley GT, Belanger SE, ...
  • HESI - Health and Environmental Sciences Institute

The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs.

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Investigating Endocrine Disrupting Properties of Chemicals in Fish and Amphibians: Opportunities to Apply the 3Rs

Integrated Environmental Assessment and Management, 2021

Burden N, Embry MR, Hutchinson TH, Lynn SG, Maynard SK, ...

Many regulations are beginning to explicitly require investigation of a chemical's endocrine disrupting properties as a part of the safety assessment process, for substances already on or about to be placed on the market. Different jurisdictions are applying distinct approaches. However, all share a common theme requiring ...

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Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
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