Binding of hydrophobic chemicals to colloids such as proteins or lipids is difficult to measure using classical microdialysis methods due to low aqueous concentrations, adsorption to dialysis membranes and test vessels, and slow kinetics of equilibration.
Protein and Lipid Binding Parameters in Rainbow Trout (Oncorhynchus Mykiss) Blood And Liver Fractions to Extrapolate From an In Vitro Metabolic Degradation Assay to In Vivo Bioaccumulation Potential of Hydrophobic Organic Chemicals
Chemical Research in Toxicology, 2011