Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Coulson M, Bickerton S, Betts CJ, Jacobsen M, Stewart J, ...
- HESI - Health and Environmental Sciences Institute
A cross-laboratory analytic evaluation of a commercially available human inhibin B ELISA for measuring inhibin B in rat serum and plasma has been undertaken.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Coulson M, Mitchard T, Bickerton S, Harris J, Betts C, Stewart J
- HESI - Health and Environmental Sciences Institute
This study examined the correlation between Inhibin B and testicular pathology.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Enright BP, Tornesi B, Lorenz H, Whitney K
- HESI - Health and Environmental Sciences Institute
This study was conducted as part of an ILSI-HESI consortium effort to assess the utility of circulating inhibin B as an early biomarker of testicular toxicity in rats.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Erdos Z, Pearson K, Goedken M, Menzel K, Sistare FD, Glaab WE, ...
- HESI - Health and Environmental Sciences Institute
Inhibin B is a heterodimer glycoprotein that downregulates follicle-stimulating hormone and is produced predominantly by Sertoli cells.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Moffit JS, Her LS, Mineo AM, Knight BL, Phillips JA, Thibodeau MS
- HESI - Health and Environmental Sciences Institute
Although histopathology is considered the gold standard for assessing testicular toxicity in the nonclinical setting, identification of noninvasive biomarkers for testicular injury are desirable to improve safety monitoring capabilities for clinical trials.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Chapin RE, Alvey JD, Goldstein RA, Dokmanovich MG, Reagan WJ, ...
- HESI - Health and Environmental Sciences Institute
Serum Inhibin B was measured in two studies of known testis-toxic drug candidates.
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