Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Inhibin B as a Marker of Sertoli Cell Damage and Spermatogenic Disturbance in the Rat

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013

Pfaff T, Rhodes J, Bergmann M, Weinbauer GF
  • HESI - Health and Environmental Sciences Institute

This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment-free period in control and 30, 60, and 180 mg/kg dose groups (n = 22/group).

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Incorporating Human Exposure Information in a Weight of Evidence Approach to Inform Design of Repeated Dose Animal Studies

Regulatory Toxicology and Pharmacology, 2021

Lowe K, Dawson J, Phillips K, Minucci J, Wambaugh JF, Qian H, ...

Human health risks from chronic exposures to environmental chemicals are typically estimated from potential human exposure estimates and dose-response data obtained from repeated-dose animal toxicity studies. Various criteria are available for selecting the top (highest) dose used in these animal studies. For example, ...

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In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials

Frontiers in Toxicology, Nanotoxicology, 2022

Cardoso R, Dusinska M, Collins A, Manjanatha M, Pfuhler S, ...

The in vivo Comet assay measures the generation of DNA strand breaks under conditions in which the DNA will unwind and migrate to the anode in an electrophoresis assay, producing comet-like figures. Measurements are on single cells, which allows the sampling of a diversity of cells and tissues for DNA damaging effects. The Comet ...

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In Vitro Testicular Toxicity Models: Opportunities for Advancement via Biomedical Engineering Techniques

ALTEX, 2013

Saldutti LP, Beyer BK, Breslin W, Brown TR, Chapin RE, Campion S, ...
  • HESI - Health and Environmental Sciences Institute

To address the pressing need for better in vitro testicular toxicity models, a workshop sponsored by the International Life Sciences Institute (ILSI), the Health and Environmental Science Institute (HESI), and the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), was held at the Mt. Washington ...

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