Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Erdos Z, Pearson K, Goedken M, Menzel K, Sistare FD, Glaab WE, ...
- HESI - Health and Environmental Sciences Institute
Inhibin B is a heterodimer glycoprotein that downregulates follicle-stimulating hormone and is produced predominantly by Sertoli cells.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Moffit JS, Her LS, Mineo AM, Knight BL, Phillips JA, Thibodeau MS
- HESI - Health and Environmental Sciences Institute
Although histopathology is considered the gold standard for assessing testicular toxicity in the nonclinical setting, identification of noninvasive biomarkers for testicular injury are desirable to improve safety monitoring capabilities for clinical trials.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Chapin RE, Alvey JD, Goldstein RA, Dokmanovich MG, Reagan WJ, ...
- HESI - Health and Environmental Sciences Institute
Serum Inhibin B was measured in two studies of known testis-toxic drug candidates.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Pfaff T, Rhodes J, Bergmann M, Weinbauer GF
- HESI - Health and Environmental Sciences Institute
This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment-free period in control and 30, 60, and 180 mg/kg dose groups (n = 22/group).
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Sonee M, Bogdan N, Hall L, Bryant S, Vinken P
- HESI - Health and Environmental Sciences Institute
This study was conducted as part of an ILSI-HESI International Life Sciences Institute-Health & Environmental Sciences Institute consortium effort to assess the utility of circulating Inhibin B as an early biomarker of Sertoli cell-specific testicular toxicity in rats.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Stewart J, Bickerton S, Betts CJ, Kirk S
- HESI - Health and Environmental Sciences Institute
Inhibin B was measured in plasma samples obtained from 34 healthy male subjects selected on criteria typical for a phase I clinical trial across a wide age range (19–70 years).
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