Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Inter-Laboratory Optimization of Protein Extraction, Separation, and Fluorescent Detection of Endogenous Rice Allergens

Bioscience, Biotechnology, Biochemistry, 2016

Satoh R, Teshima R, Kitta K, Lang GH, Schegg K, Blumenthal K, ...

In rice, several allergens have been identified such as the non-specific lipid transfer protein-1, the α-amylase/trypsin-inhibitors, the α-globulin, the 33 kDa glyoxalase I (Gly I), the 52–63 kDa globulin, and the granule-bound starch synthetase. The goal of the present study was to define optimal rice extraction and ...

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Comparing Rat and Rabbit Embryo-Fetal Developmental Toxicity Data for 379 Pharmaceuticals: On Systemic Dose and Developmental Effects

Critical Reviews in Toxicology , 2016

Theunissen PT, Beken S, Beyer B, Breslin WJ, Cappon GD, Chen CL, ...

A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental lowest adverse effect level (dLOAEL). For the vast ...

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Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

Critical Reviews in Toxicology , 2016

Peter T. Theunissen, Sonja Beken, Bruce K. Beyer, ...
  • HESI - Health and Environmental Sciences Institute

Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo–fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT testing could be limited to one species, or whether the testing in a second ...

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Standardized Cell sources and Recommendations for Good Cell Culture Practices in Genotoxicity Testing

Mutation Research/Genetic Toxicology and Environmental Mutagenesis. (2016) 809: 1–15., 2016

E. Lorge, M.M. Moore, J. Clements, M. O’Donovan, M.D. Fellows, ...
  • HESI - Health and Environmental Sciences Institute

Good cell culture practice and characterization of the cell lines used are of critical importance in in vitro genotoxicity testing. The objective of this initiative was to make continuously available stocks of the characterized isolates of the most frequently used mammalian cell lines in genotoxicity testing anywhere in the ...

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Next-generation testing strategy for assessment of genomic damage: a conceptual framework and considerations.

Environmental and Molecular Mutagenesis, 2016

Dearfield KL, Gollapudi BB, Bemis JC, Benz RD, Douglas GR, ...
  • HESI - Health and Environmental Sciences Institute

 

To enable the broader context for examining genetic damage, a next generation testing strategy needs to take into account a broader, more flexible approach to testing, and ultimately modeling, of genomic damage as it relates to human exposure. The outline of a flexible ...

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Cytokine Release: A Workshop Proceedings on the State-of-the-Science, Current Challenges and Future Directions

Cytokine, 2016

Grimaldi C, Finco D, Fort MM, Gliddon D, Harper K, Helms WS, ...

In October 2013, the Health and Environmental Sciences Institute Immuno-Safety Technical Committee (ITC) held a one-day workshop entitled, “Workshop on Cytokine Release: State-of-the-Science, Current Challenges and Future Directions”. The workshop brought together scientists from pharmaceutical, academic, ...

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