Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Repolarization Studies Using Human Stem Cell-Derived Cardiomyocytes: Validation Studies and Best Practice Recommendations

Regulatory Toxicology and Pharmacology, 2020

Gintant G, Kaushik EP, Feaster T, Stoelzle-Feix S, Kanda Y, ...
  • HESI - Health and Environmental Sciences Institute

Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the ability of hSC-CMs to detect drug-induced delayed ...

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Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Toxicological Sciences, 2018

Nichols J, Fay K, Bernhard MJ, Bischof I, Davis J, Halder M, Hu J, ...

The HESI Bioaccumulation Technical Committee completed a study highlighting several issues related to the demonstration of assay reliability and provided a template for evaluating other in vitro biotransformation assays. The results are published here.

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Relationships Between p53 Status, Apoptosis and Induction of Micronuclei in Different Human and Mouse Cell Lines In Vitro: Implications for Improving Existing Assays

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2015

Whitwell J, Smith R, Jenner K, Lyon H, Wood D, Clements J, ...
  • HESI - Health and Environmental Sciences Institute

Accumulated evidence has shown that in vitro mammalian cell genotoxicity assays produce high frequencies of "misleading" positive results, i.e. predicted hazard is not confirmed in in vivo and/or carcinogenicity studies [1], raising the question of relevance to human risk assessment.

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