Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Creation of a Curated Aquatic Toxicology Database: EnviroTox

Environmental Toxicology and Chemistry, 2019

Connors KA, Beasley A, Barron MG, Belanger SE, Bonnell M, ...

The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.

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Critical Evaluation of Current Developmental Toxicity Testing Strategies: A Case of Babies and Their Bathwater

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2011

Carney EW, Ellis AL, Tyl RW, Foster P, Scialli AR, Thompson K, ...
  • HESI - Health and Environmental Sciences Institute

This review is the second in a series of four papers emanating from a workshop entitled “Developmental Toxicology—New Directions,” which was sponsored by the ILSI Health and Environmental Sciences Institute's (HESI) Developmental and Reproductive Toxicology Technical Committee.

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Cross-Company Evaluation of the Human Lymphocyte Activation Assay

Journal of Immunotoxicology, 2020

Collinge M, Schneider P, Li D, Parish S, Dumont C, Freebern W, ...

Nonclinical immunotoxicity evaluation is an important component of safety assessment for pharmaceuticals. One in vitro assay that can be applied in a weight of evidence assessment is the human lymphocyte activation (HuLA) assay, an antigen recall assay, similar in many respects to the in vivo T-cell-dependent ...

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Cross-Site and Cross-Platform Variability of Automated Patch Clamp Assessments of Drug Effects on Human Cardiac Currents in Recombinant Cells

Nature Scientific Reports, 2020

Kramer J, Himmel HM, Lindqvist A, Stoelzle-Feix S, Chaudhary KW, ...

Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability of IC50 values characterizing drug block ...

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