Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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A Critical Review of Bioaccumulation and Biotransformation of Organic Chemicals in Birds

Reviews of Environmental Contamination and Toxicology, 2022

Kuo DTF, Rattner BA, Marteinson SC, Letcher R, Fernie KJ, Treu G, ...

A literature review of bioaccumulation and biotransformation of organic chemicals in birds was undertaken, aiming to support scoping and prioritization of future research. The objectives were to characterize available bioaccumulation/ biotransformation data, identify knowledge gaps, determine how extant data can be ...

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A Cross-Sector Call to Improve Carcinogenicity Risk Assessment Through Use of Genomic Methodologies

Regulatory Toxicology and Pharmacology, 2019

Yauk CL, Harrill AH, Ellinger-Ziegelbauer H, van der Laan JW, ...

Robust genomic approaches are now available to realize improvements in efficiencies and translational relevance of cancer risk assessments for drugs and chemicals. The authors propose a path for implementation of innovative cancer risk assessment including incorporating genomic signatures to assess mechanistic relevance ...

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A Database of Fish Biotransformation Rates for Organic Chemicals

Environmental Toxicology and Chemistry, 2008

Arnot JA, Mackay D, Parkerton TF, Bonnell M
  • HESI - Health and Environmental Sciences Institute

Biotransformation is a key process that can mitigate the bioaccumulation potential of organic substances and is an important parameter for exposure assessments.

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A Different Approach to Validating Screening Assays for Developmental Toxicity

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2010

Daston GP, Chapin RE, Scialli AR, Piersma AH, Carney EW, ...
  • HESI - Health and Environmental Sciences Institute

There continue to be many efforts around the world to develop assays that are shorter than the traditional embryofetal developmental toxicity assay, or use fewer or no mammals, or use less compound, or have all three attributes.

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A Framework for Cumulative Risk Assessment in the 21st Century

Critical Reviews in Toxicology, 2016

Moretto A, Bachman A, Boobis A, Solomon KR, Pastoor TP, Wilks MF, ...

The Health and Environmental Sciences Institute (HESI) has developed a framework to support a transition in the way in which information for chemical risk assessment is obtained and used. The approach is based on detailed problem formulation, where exposure drives the data acquisition process in order to enable informed ...

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Health and Environmental Sciences Institute (HESI)

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