Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Postnatal Growth and Morphological Development of the Brain: A Species Comparison

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2006

Watson RE, DeSesso JM, Hurtt ME, Cappon GD
  • HESI - Health and Environmental Sciences Institute

The objective of this report is to summarize the available literature regarding the postnatal growth and morphological development of the brain and compare the timelines for these events between humans and experimental species.

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HESI Cardiovascular Safety Subcommittee Initiative: Evaluation of Three Non-Clinical Models of QT Prolongation

Journal of Pharmacological and Toxicological Methods, 2006

Hanson LA, Bass AS, Gintant G, Mittelstadt S, Rampe D, Thomas K
  • HESI - Health and Environmental Sciences Institute

Drugs that delay cardiac repolarization pose potential safety risks to patients and cause serious regulatory concern because of the link between QT interval prolongation and the potentially fatal arrhythmia torsades de pointes (TdP).

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Assessing the Potential to Induce Respiratory Hypersensitivity

Toxicological Sciences, 2006

Holsapple MP, Jones D, Kawabata TT, Kimber I, Sarlo K, ...
  • HESI - Health and Environmental Sciences Institute

Acute and repeat dose inhalation studies have been an important part of the safety assessment of drugs, chemicals, and other products throughout the world for many years.

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Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk

Toxicological Sciences, 2006

Holsapple MP, Pitot HC, Cohen SH, Boobis AR, Klaunig JE, ...
  • HESI - Health and Environmental Sciences Institute

Hazard identification and risk assessment paradigms depend on the presumption of the similarity of rodents to humans, yet species specific responses, and the extrapolation of high-dose effects to low-dose exposures can affect the estimation of human risk from rodent data.

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Health and Environmental Sciences Institute (HESI)

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