Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Summary of a Workshop on Preclinical and Translational Safety Assessment of CD3 Bispecifics

Journal of Immunotoxicology, 2020

Kamperschroer C, Shenton J, Lebrec H, Leighton JK, Moore PA, ...

Currently, there is a multitude of CD3 bispecifics with different molecular designs and binding properties in preclinical and clinical development for the treatment of liquid or solid tumors. The key safety concerns with CD3 bispecifics are excessive release of cytokines, which may translate to potentially life-threating ...

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Strategic Biomonitoring Initiatives: Moving the Science Forward

Toxicological Sciences, 2006

Angerer J, Bird MG, Burke TA, Doerrer NG, Needham L, Robison SH, ...
  • HESI - Health and Environmental Sciences Institute

Biomonitoring programs in the United States and Europe demonstrate the vast array of data that are publicly available for the evaluation of exposure trends, identification of susceptible populations, detection of emerging chemical risks, the conduct of epidemiology studies, and evaluation of risk reduction strategies.

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State of the Art in Developmental Toxicity Screening Methods and a Way Forward: A Meeting Report Addressing Embryonic Stem Cells, Whole Embryo Culture, and Zebrafish

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2008

Chapin R, Augustine‐Rauch K, Beyer B, Daston G, Finnell R, ...
  • HESI - Health and Environmental Sciences Institute

A meeting was convened so that users of three models for in vitro developmental toxicity (embryonic stem cells, whole embryo culture, and zebrafish) could share their experiences with each model, and explore the areas for improvement.

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Standardized Cell sources and Recommendations for Good Cell Culture Practices in Genotoxicity Testing

Mutation Research/Genetic Toxicology and Environmental Mutagenesis. (2016) 809: 1–15., 2016

E. Lorge, M.M. Moore, J. Clements, M. O’Donovan, M.D. Fellows, ...
  • HESI - Health and Environmental Sciences Institute

Good cell culture practice and characterization of the cell lines used are of critical importance in in vitro genotoxicity testing. The objective of this initiative was to make continuously available stocks of the characterized isolates of the most frequently used mammalian cell lines in genotoxicity testing anywhere in the ...

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