Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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A comparative analysis of select P450 enzymes in uninduced and PB/BNF-induced hamster and rat liver S9

Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 2025

Evans et al.

As part of its Nitrosamine Research Program (NRP), HESI’s Genetic Toxicology Technical Committee (GTTC) has supported the publication of a new study evaluating the relative CYP enzyme activities in uninduced and induced hamster and rat liver S9 preparations. This research is critical for assessing the metabolic ...

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Control Performance of Amphibian Metamorphosis Assays with Xenopus laevis

Regulatory Toxicology and Pharmacology, 2025

Wheeler et al.

This study addresses variability challenges in the Amphibian Metamorphosis Assay (AMA), a widely used assay to detect the endocrine-disrupting effects of chemicals on the thyroid system. By analyzing data from 52 studies across seven laboratories, the paper highlights how variability in controls affects the assay's ...

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