EPA guidelines provide a choice in evaluating humoral immune system function in rats and mice immunized with sheep red blood cells (sRBC): an antibody-forming cell (AFC) assay or a sRBC-specific serum IgM enzyme-linked immunosorbent assay (ELISA).
Interlaboratory Study of the Primary Antibody Response to Sheep Red Blood Cells in Outbred Rodents Following Exposure to Cyclophosphamide or Dexamethasone
Journal of Immunotoxicology, 2007