Workshop on the Molecular and Genetic Basis of Potential Unintended Effects in Modified Plants

Final Program

09:00 Meeting Overview and Objectives
Dr. Scott McClain – HESI PATC Committee Co-Chair

SESSION 1. MOLECULAR AND GENETIC BASIS OF UNINTENDED EFFECTS (09:15 – 11:45)

Important Concepts:

• Basic biology of mutations
• Perceived versus actual risk of unintended effects

09:15 Genetic basis and examples of potential unintended effects due to genetic engineering and breeding
Dr. Jaimie Schnell, Canadian Food Inspection Agency, Canada

10:00 Evaluating the occurrence of unintended effects through nutritional compositional analysis studies
Dr. Phil Brune, Syngenta

10:45 BREAK

11:00 The Biology of Naturally Occurring Insertions
Dr. Justin Vaughn, University of Georgia

11:45 LUNCH

SESSION 2. ENDOGENOUS ALLERGENICITY ASSESSMENT (13:00 – 14:30)

Important Concepts:

• Perceived vs actual risk of the potential to change endogenous allergens
• Natural variability versus changes due to GM insertion

13:00 Perceived versus actual risk of the potential to change endogenous allergens
Dr. Greg Ladics, DuPont Pioneer, US

13:45 Natural variability versus changes due to GM insertion
Dr. Jason Ward, Monsanto Company, US

14:30 BREAK

SESSION 3. CONSEQUENCES OF UNINTENDED EFFECTS ON THE FOOD AND FEED SAFETY ASSESSMENT OF MODIFIED PLANTS (14:45 – 16:00)

Important Concepts:

• Process of Modified Plant Development
• Role of long term animal feeding studies to assess unintended effects

14:45 Process of modified plant development
Dr. Laura Privalle, Bayer CropScience, US

15:15 Use of animal feeding studies to assess unintended effects
Prof. Andrew Bartholomaeus, University of Canberra, University of Queensland, Australia

15:45 EU view of unintended effects
Dr. Antonio Fernandez Dumont, EFSA, EU

16:15 Canada's view of unintended effects regarding food and feed assessments
Mr. Luc Bourbonniere, Health Canada

PANEL DISCUSSION and SUMMARY (16:15 – 17:15)

Moderator: Dr. Scott McClain – HESI PATC Committee Co-Chair

Panelists [all speakers]

17:15 Adjourn

This event was sponsored by the HESI Protein Allergenicity Technical Committee (PATC).